Product Pathways - Phosphatases
PPP2R5D (H5D12) Mouse mAb #5687
|W IP||H M R Mk||Endogenous||66, 69 kDa||Mouse IgG1|
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
PPP2R5D (H5D12) Rabbit mAb recognizes endogenous levels of total PPP2R5D/PP2A, B'-δ/B56-δ protein. This antibody cross-reacts with PPP2R4 and PPP2R2A protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human PPP2R5D protein.
Protein Phosphatase 2A subunit isoform R5-δ (PPP2R5D) belongs to the R5/B'/B56 family of the regulatory subunit B of serine/threonine phosphatase 2A (1). PPP2R5D (B-δ) is structurally related to the other components of subunit B, B-α. PPP2R5D lacks the WD-40 repeats that are important for protein-protein interaction (1-2). Structural differences may contribute to distinct down stream effects (3) and directing PP2A nuclear localization (4). Current evidence suggests that in contrast to B-α, PPP2R5D modulates the TGF-β/Actividin/Nodal signaling pathways by restricting the downstream activities of the type I TGF-β receptors, ALK4, and ALK5 (3)
- McCright, B. and Virshup, D.M. (1995) J Biol Chem 270, 26123-8.
- Neer, E.J. et al. (1994) Nature 371, 297-300.
- Batut, J. et al. (2008) Development 135, 2927-37.
- McCright, B. et al. (1996) J Biol Chem 271, 22081-9.
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For Research Use Only. Not For Use In Diagnostic Procedures.