Product Pathways - Cell Cycle / Checkpoint
LATS2 (D83D6) Rabbit mAb #5888
|5888S||100 µl (10 western blots)||---||In Stock||---|
|5888||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human||Transfected Only||150||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Species predicted to react based on 100% sequence homology: Monkey.
Specificity / Sensitivity
LATS2 (D83D6) Rabbit mAb detects transfected levels of total LATS2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human LATS2 protein.
LATS2 is an AGC kinase of the NDR family of kinases. It is a tumor suppressor of the LATS family, and plays a critical role in centrosome duplication, maintenance of mitotic fidelity, and genomic stability (1). LATS2 inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity (2). It also plays an important role in regulation of the Hippo pathway, a pathway that is important in controlling organ size and tumor progression by regulating cellular proliferation and promoting apoptosis (3,4,5)
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For Research Use Only. Not For Use In Diagnostic Procedures.
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