Product Pathways - Cell Cycle / Checkpoint
LATS2 (D83D6) Rabbit mAb #5888
|5888S||100 µl (10 western blots)||---||In Stock||---|
|5888||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human||Transfected Only||150||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Species predicted to react based on 100% sequence homology: Monkey.
Specificity / Sensitivity
LATS2 (D83D6) Rabbit mAb detects transfected levels of total LATS2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human LATS2 protein.
Large tumor suppressor kinase 2 (LATS2) is an AGC kinase of the NDR family of kinases. It is a LATS family tumor suppressor that plays a critical role in centrosome duplication, maintenance of mitotic fidelity, and genomic stability (1). LATS2 inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity (2). It also plays an important role in regulation of the Hippo pathway, which is important in controlling organ size and tumor progression by regulating cellular proliferation and promoting apoptosis (3-5).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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