Product Pathways - Cell Cycle / Checkpoint
LATS2 (D83D6) Rabbit mAb #5888
|W||H (Mk)||Transfected Only||150||Rabbit IgG|
Reactivity Key: H=Human Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
LATS2 (D83D6) Rabbit mAb detects transfected levels of total LATS2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human LATS2 protein.
LATS2 is an AGC kinase of the NDR family of kinases. It is a tumor suppressor of the LATS family, and plays a critical role in centrosome duplication, maintenance of mitotic fidelity, and genomic stability (1). LATS2 inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity (2). It also plays an important role in regulation of the Hippo pathway, a pathway that is important in controlling organ size and tumor progression by regulating cellular proliferation and promoting apoptosis (3,4,5)
- Yabuta, N. et al. (2007) J Biol Chem 282, 19259-71.
- Li, Y. et al. (2003) Oncogene 22, 4398-405.
- Harvey, K. and Tapon, N. (2007) Nat Rev Cancer 7, 182-91.
- Zeng, Q. and Hong, W. (2008) Cancer Cell 13, 188-92.
- Visser, S. and Yang, X. (2010) Cell Cycle 9, 3892-903.
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For Research Use Only. Not For Use In Diagnostic Procedures.