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Synapsin-1 (D13C1) Rabbit mAb #6710

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PhosphoSitePlus^® protein, site, and accession data: SYN1

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M R	Endogenous	77	Rabbit IgG

Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Protocols

6710:: Immunoprecipitation, Western Blotting

Specificity / Sensitivity

Synapsin-1 (D13C1) Rabbit mAb detects endogenous levels of total synapsin-1 protein. The antigen is 100% conserved between human synapsin-1a and synapsin-1b.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro575 of human synapsin-1 protein.

Western Blotting

Western blot analysis of extracts from mouse, rat, and fetal rat brain using Synapsin-1 (D13C1) Rabbit mAb.

Background

Synapsins, a group of at least five related members (synapsins Ia, Ib, IIa, IIb, and IIIa), are abundant brain proteins essential for regulating neurotransmitter release (1,2). All synapsins contain a short amino-terminal domain that is highly conserved and phosphorylated by PKA or CaM kinase I (1). Phosphorylation of the synapsin amino-terminal domain at Ser9 inhibits its binding to phospholipids and dissociates synapsins from synaptic vesicles (2).

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For Research Use Only. Not For Use In Diagnostic Procedures.