Cell Signaling Technology

Product Pathways - Metabolism

PANK2 Antibody (Mouse Specific) #6923

Applications Reactivity Sensitivity MW (kDa) Source
W IP M Endogenous 49 Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Protocols

Specificity / Sensitivity

PANK2 Antibody (Mouse Specific) recognizes endogenous levels of total PANK2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of mouse PANK2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Western Blotting

Western Blotting

Western blot analysis of extracts from mouse testis using PANK2 Antibody (Mouse Specific).

Background

PANK2, pantothenate kinase 2, catalyzes the first step in CoA biosynthesis (1, 2). Human PANK2 is located in the mitochondria, and some mutations in human PANK2 are linked to neurodegeneration (2). Alternatively, mouse PANK2 localizes in the cytosol, and defective PANK2 in mice leads to retinal degeneration (1, 2).

  1. Leonardi, R. et al. (2007) FEBS Lett 581, 4639-44.
  2. Zhang, Y.M. et al. (2006) J Biol Chem 281, 107-14.
  3. Kuo, Y.M. et al. (2005) Hum Mol Genet 14, 49-57.

Application References

Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!

Companion Products

For Research Use Only. Not For Use In Diagnostic Procedures.

Products