Product Pathways - Phosphatases
CTDSPL2 (D79G11) Rabbit mAb #6932
|W||H R Mk||Endogenous||62||Rabbit IgG|
Reactivity Key: H=Human R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
CTDSPL2 (D79G11) Rabbit mAb recognizes endogenous levels of total CTDSPL2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CTDSPL2 protein.
CTD small phosphatase-like protein 2 (CTDSPL2, HSPC129) is a putative RNA-polymerase II carboxy-terminal domain (CTD) phosphatase (1) that belongs to a small subfamily of CTD phosphatases (2). The CTD of RNA polymerase II contains multiple Y-S-P-T-S-P-S repeats that are phosphorylated during the transcription cycle (3,4). In general, CTD phosphatases regulate the reversible CTD phosphorylation state of RNA-polymerase II at several stages of RNA synthesis and during post-transcriptional modification (4-6). CTDSPL2 has several structural and functional similarities to other CTD phosphatases, including FCP1, SCP1, DULLARD, and UBLCP1 (1,2).
- Qian, H. et al. (2007) Mol Cell Biochem 303, 183-8.
- Kim, Y. et al. (2007) Proc Natl Acad Sci USA 104, 6596-601.
- Corden, J.L. et al. (1985) Proc Natl Acad Sci USA 82, 7934-8.
- Ahn, S.H. et al. (2004) Mol Cell 13, 67-76.
- Dahmus, M.E. (1996) J Biol Chem 271, 19009-12.
- Goodrich, J.A. and Tjian, R. (1994) Cell 77, 145-56.
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