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XML generation date: 2026-06-05 17:29:08.510
Product last modified at: 2026-03-20T08:02:17.476Z
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PDP - Template Name: Assay Kit
PDP - Template ID: *******4838e4e
  1. Products /
  2. Cellular Assay Kits /
  3. HTScan® VEGF Receptor 1 Kinase Assay Kit

HTScan® VEGF Receptor 1 Kinase Assay Kit #7785

Inquiry Info. # 7785

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    Product Information

    Product Description

    The kit provides a means of performing kinase activity assays with recombinant human VEGFR-1 kinase. It includes active VEGFR-1 kinase (supplied as a GST fusion protein), a biotinylated peptide substrate and a phospho-tyrosine antibody for detection of the phosphorylated form of the substrate peptide.
    Molecular Formula Peptide substrate, Biotin-Gastrin Precursor (Tlyr87): 2,853 Daltons. GST-VEGFR-1 Kinase: 89 kDa.

    Background

    The vascular endothelial growth factor (VEGF) receptor (VEGFR-1, Flt-1) is a 180 kDa receptor tyrosine kinase belonging to the VEGFR (Flt) family (1-3). The receptor is comprised of seven extracellular Ig-like domains, a single transmembrane region and cytoplasmic tail containing the active kinase domain (1,2). VEGFR-1 plays an important role in endothelial cell function and normal vascular development, as well as in hematopoietic function (2,3). VEGF-A is a high affinity ligand of VEGFR-1. VEGFR-1 also binds VEGF-B and PLGF (2). Ligand binding results in very little VEGFR-1 kinase activation, and VEGFR-1/VEGF-A binding negatively regulates VEGF function by diverting the growth factor from other functional VEGF receptors (3).

    Alternate Names

    Flt-1; high throughput; HTS; htscankit; kinase assay; screening; tyrosine kinase; VEGF; VEGFR; VEGFR1

    Database Links

    UniProt ID: P17948


    Entrez-Gene Id: 2321


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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