Product Pathways - Protein Folding
Hip (10B7-C3) Mouse mAb #8014
|W IP||H M R Mk||Endogenous||49||Mouse IgG2a|
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
Hip (10B7-C3) Antibody detects endogenous levels of total Hip (Hsc70-interacting) protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to rat Hip protein.
Hip (HSP70-interacting protein), also known as ST13 (suppression of tumorigenicity protein 13), is one of several co-chaperones that regulate activities of the HSP70 chaperone family (1,2). The homo-oligomeric protein Hip cooperates with HSP70 in protein folding by stabilizing the ADP-bound state of HSP70. Hip directly binds to the ATPase domain of HSP70 when it is converted to the ADP-bound state by proteins of the HSP40 family (3). By collaborating with other positive co-factors such as HSP40 and Hop, or competing with negative co-factors such as Bag1, Hip may facilitate the chaperone function of HSP70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid receptors and various regulators of proliferation or apoptosis (4-8).
- Prapapanich, V. et al. (1996) Mol. Endocrino.l 10, 420-431.
- Gebauer, M. et al. (1997) FEBS Lett. 417, 109-113.
- Höhfeld, J. et al. (1995) Cell 83, 589-.98.
- Frydman, J. and Höhfeld, J. (1997) Trends Biochem. Sci. 22, 87-92.
- Nollen, E.A. et al. (2001) J. Biol. Chem. 276, 4677-4682.
- Fan, G.H. et al. (2002) J. Biol. Chem. 277, 6590-6597.
- Nelson, G.M. et al. (2004) Mol. Endocrinol. 18, 1620-1630.
- Shi, Z.Z. et al. (2007) J. Zhejiang Univ. Sci. B. 8, 170-176.
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For Research Use Only. Not For Use In Diagnostic Procedures.