Product Pathways - Tyrosine Kinase / Adaptors
Src (36D10) Rabbit mAb (Biotinylated) #8048
|W||H M R Hm Mk B Pg (C)||Endogenous||60||Rabbit IgG|
Reactivity Key: H=Human M=Mouse R=Rat Hm=Hamster Mk=Monkey C=Chicken B=Bovine Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
Src (36D10) Rabbit mAb (Biotinylated) detects endogenous levels of total Src protein. The antibody may cross-react with other Src family members, but does not cross-react with other non-family proteins.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Src protein.
This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The biotinylated antibody is expected to exhibit the same species cross-reactivity as the unconjugated Src (36D10) Rabbit mAb #2109.
The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regulation of growth and differentiation of eukaryotic cells (1). Src activity is regulated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the activation loop of the kinase domain upregulates enzyme activity, phosphorylation at Tyr527 in the carboxy-terminal tail by Csk renders the enzyme less active (2).
- Thomas, S.M. and Brugge, J.S. (1997) Annu. Rev. Cell Dev. Biol. 13, 513-609.
- Hunter, T. (1987) Cell 49, 1-4.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
- 2123 Src (32G6) Rabbit mAb
- 3999 Streptavidin-HRP
- 2101 Phospho-Src Family (Tyr416) Antibody
- 2110 Src (L4A1) Mouse mAb
- 2108 Src Antibody
- 2109 Src (36D10) Rabbit mAb
Rabbit monoclonal antibody is produced under license (granting certain rights including those under U. S. Patents No. 5,675,063 and 7,429,487) from Epitomics, Inc.
For Research Use Only. Not For Use In Diagnostic Procedures.