Product Pathways - Metabolism
Insulin (L6B10) Mouse mAb #8138
|8138S||100 µl (10 western blots)||---||In Stock||---|
|8138||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation, IF-F=Immunofluorescence (Frozen)
Species predicted to react based on 100% sequence homology: Human, Mouse.
Specificity / Sensitivity
Insulin (L6B10) Mouse mAb recognizes endogenous levels of total insulin and proinsulin.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val36 of human insulin.
The maintenance of glucose homeostasis is an essential physiological process that is regulated by hormones. An elevation in blood glucose levels during feeding stimulates insulin release from pancreatic β cells through a glucose sensing pathway (1). Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to secretion. A- and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide. Insulin stimulates glucose uptake from blood into skeletal muscle and adipose tissue. Insulin deficiency leads to type 1 diabetes mellitus (2).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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