Product Pathways - Nuclear Receptor Signaling
Androgen Receptor (D6F11) XP® Rabbit mAb (PE Conjugate) #8428
|8428S||100 µl (50 tests)||---||In Stock||---|
|8428||carrier free and custom formulation / quantity||email request|
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Applications Key: F=Flow Cytometry
Specificity / Sensitivity
Androgen Receptor (D6F11) XP® Rabbit mAb (PE Conjugate) detects endogenous levels of total androgen receptor protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a recombinant protein corresponding to residues near the amino terminal region of human androgen receptor protein.
This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in human cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated Androgen Receptor (D6F11) XP® Rabbit mAb #5153.
Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. Research studies have shown that AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3).
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For Research Use Only. Not For Use In Diagnostic Procedures.
XP® is a trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.