Product Pathways - Translational Control
LSm2 Antibody #8498
|W||H M R Mk||Endogenous||11||Rabbit|
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
LSm2 Antibody recognizes endogenous levels of total LSm2 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val77 of human LSm2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
LSm proteins are members of an ancient family of RNA binding proteins that function in RNA metabolism (1,2). Two LSm complexes have been identified: LSm1-7 and LSm2-8 (1). LSm1-7 complex is involved in mRNA degradation (3). LSm2-8 complex is required for pre-tRNA and rRNA maturation (4,5), and regulates pre-mRNA splicing through its association with U6 snRNA (6). Recent studies show that LSm2-8 complex functions in the biogenesis of telomerase RNA (1).
- Tang, W. et al. (2012) Nature 484, 260-4.
- Wilusz, C.J. and Wilusz, J. (2005) Nat Struct Mol Biol 12, 1031-6.
- Tharun, S. et al. (2000) Nature 404, 515-8.
- Kufel, J. et al. (2002) Mol Cell Biol 22, 5248-56.
- Kufel, J. et al. (2003) J Biol Chem 278, 2147-56.
- Mayes, A.E. et al. (1999) EMBO J 18, 4321-31.
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For Research Use Only. Not For Use In Diagnostic Procedures.