Product Pathways - Translational Control
hnRNP E1 Antibody #8534
|W IP||H M R||Endogenous||40||Rabbit|
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
hnRNP E1 Antibody recognizes endogenous levels of total hnRNP E1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys237 of human hnRNP E1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
hnRNP E1 is a member of the hnRNP family of proteins that are involved in pre-mRNA processing and mRNA export, localization, stability, and translation (1-6). hnRNP E1 exerts a wide range of biological functions, such as transcriptional activation of mouse MOR gene expression (7), attenuation of alternative splicing of GHR pseudoexon expression (8), stabilization of collagen I and II (9), beta-globin (10), and androgen receptor (11) mRNAs, and regulation of translation of various genes including Dab2, ILEI, and Bag-1 (12,13). hnRNP E1 is ubiquitously expressed. Phosphorylation of hnRNP E1 affects its RNA binding affinity (13,14).
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- Gallouzi, I.E. and Steitz, J.A. (2001) Science 294, 1895-901.
- Carson, J.H. et al. (2001) Results Probl Cell Differ 34, 69-81.
- Xu, K. et al. (2001) J Immunol 166, 6358-66.
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- Dreyfuss, G. et al. (2002) Nat Rev Mol Cell Biol 3, 195-205.
- Kim, S.S. et al. (2005) Mol Pharmacol 68, 729-36.
- Akker, S.A. et al. (2007) Mol Endocrinol 21, 2529-40.
- Thiele, B.J. et al. (2004) Circ Res 95, 1058-66.
- Yu, J. and Russell, J.E. (2001) Mol Cell Biol 21, 5879-88.
- Yeap, B.B. et al. (2002) J Biol Chem 277, 27183-92.
- Pickering, B.M. et al. (2003) Nucleic Acids Res 31, 639-46.
- Chaudhury, A. et al. (2010) Nat Cell Biol 12, 286-93.
- Leffers, H. et al. (1995) Eur J Biochem 230, 447-53.
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For Research Use Only. Not For Use In Diagnostic Procedures.