Product Pathways - Metabolism
PCK2 (D3E11) Rabbit mAb #8565
|W IP IF-IC||H Mk||Endogenous||71||Rabbit IgG|
Reactivity Key: H=Human Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
PCK2 (D3E11) Rabbit mAb recognizes endogenous levels of total PCK2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human PCK2 protein.
Western blot analysis of extracts from various cell lines using PCK2 (D3E11) Rabbit mAb.
PCK2 (PEPCK2 or PEPCK-M) encodes an isoform of phosphoenolpyruvate carboxykinase (PEPCK) that is found in the mitochondria of renal and hepatic tissues (1). PEPCK is involved in gluconeogenesis, the process of generating glucose from non-carbohydrate substrates such as lactate and glycerol (2). PEPCK catalyzes the reaction whereby oxaloacetate becomes phosphoenolpyruvate, a rate limiting step in the metabolic process (2). The predominant function of PCK2 is to process the lactate that is continually produced by red blood cells in the liver and kidney (1).
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For Research Use Only. Not For Use In Diagnostic Procedures.