Product Pathways - Translational Control
PRP4K (D27A1) Rabbit mAb #8577
|8577S||100 µl (10 western blots)||---||In Stock||---|
|8577||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Rat, Monkey||Endogenous||150||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
PRP4K (D27A1) Rabbit mAb recognizes endogenous levels of total PRP4K protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys659 of human PRP4K protein.
PRP4K (PRP4 kinase) belongs to the Clk (Cdc-like kinase) family that recognizes serine/arginine-rich substrates (1). PRP4K is involved in pre-mRNA splicing and transcriptional regulation by interacting with components of both the U5 snRNP and the NCoR Deacetylase complexes (2,3). PRP6 and PRP31 have been shown to be direct substrates of PRP4K; their phosphorylation by PRP4K contributes to the assembly of a stable spliceosomal B complex (4).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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