Product Pathways - Metabolism
MDH2 Antibody #8610
|W||H M R||Endogenous||35||Rabbit|
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
MDH2 Antibody recognizes endogenous levels of total MDH2 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MDH2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Malate dehydrogenase (MDH) is a key enzyme in the tricarboxylic acid cycle and malate/aspartate shuttle (1,2). MDH is widely expressed in organisms from most bacteria to all eukaryotes (2). The cytoplasmic MDH isoenzyme (cMDH or MDH1) primarily reduces oxaloacetate to malate in the malate/aspartate shuttle (1-3). The major function of the mitochondrial MDH isoenzyme (mMDH or MDH2) is to oxidize malate to oxaloacetate in the tricarboxylic acid cycle (1,2).
- Matsuda, T. et al. (2010) J Pharmacol Sci 112, 320-6.
- Minárik, P. et al. (2002) Gen Physiol Biophys 21, 257-65.
- Joh, T. et al. (1987) J Biol Chem 262, 15127-31.
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For Research Use Only. Not For Use In Diagnostic Procedures.