Product Pathways - Ca / cAMP / Lipid Signaling
WFS1 Antibody #8749
|8749S||100 µl (10 western blots)||---||In Stock||---|
|8749||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Species predicted to react based on 100% sequence homology: Human.
Specificity / Sensitivity
WFS1 Antibody recognizes endogenous levels of total WFS1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala43 of human WFS1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Wolfram syndrome protein (WFS1) is an 890 amino acid protein that contains a cytoplasmic N-terminal domain, followed by nine-transmembrane domains and a luminal C-terminal domain. WFS1 is predominantly localized to the endoplasmic reticulum (ER) (1) and its expression is induced in response to ER stress, partially through transcriptional activation (2,3). Research studies have shown that mutations in the WFS1 gene lead to Wolfram syndrome, an autosomal recessive neurodegenerative disorder defined by young-onset, non-immune, insulin-dependent diabetes mellitus and progressive optic atrophy (4).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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