Product Pathways - PI3K / Akt Signaling
LAMTOR1/C11orf59 (D11H6) XP® Rabbit mAb #8975
|8975S||100 µl (10 western blots)||---||In Stock||---|
|8975P||40 µl (4 western blots)||---||In Stock||---|
|8975||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||18||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation, IHC-P=Immunohistochemistry (Paraffin), IF-IC=Immunofluorescence (Immunocytochemistry)
Specificity / Sensitivity
LAMTOR1/C11orf59 (D11H6) XP® Rabbit mAb recognizes endogenous levels of total LAMTOR1/C11orf59 protein. This antibody may cross-react with LAMTOR2/ROBLD3 and LAMTOR3/MAPKSP1.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala71 of human LAMTOR1/C11orf59 protein.
Western blot analysis of extracts from various cell lines using LAMTOR1/C11orf59 (D11H6) XP® Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using LAMTOR1/C11orf59 (D11H6) XP® Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using LAMTOR1/C11orf59 (D11H6) XP® Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded mouse colon using LAMTOR1/C11orf59 (D11H6) XP® Rabbit mAb.
mTORC1 kinase complex is a critical component in the regulation of cell growth (1,2). Its activity is modulated by energy levels, growth factors, and amino acids (3,4). The four related GTPases, RagA, RagB, RagC, and RagD, have been shown to interact with raptor in mTORC1 (1,2). These interactions are both necessary and sufficient for mTORC1 activation in response to amino acid signals (1,2). A protein complex consisting of LAMTOR1/C11orf59, LAMTOR2/ROBLD3, and LAMTOR3/MAPKSP1 has been identified to interact with and recruit the four Rag GTPases to the surface of lysosomes (5).
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For Research Use Only. Not For Use In Diagnostic Procedures.
XP® is a trademark of Cell Signaling Technology, Inc.
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Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.