Product Pathways - Tyrosine Kinase / Adaptors
Tyk2 Antibody #9312
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
Tyk2 Antibody detects endogenous levels of total Tyk2. No cross-reactivity was detected with other family members at physiological conditions.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding serine 819 of human Tyk2. Antibodies are purified by protein A and peptide affinity chromatography.
Tyk2, a member of the Jak family of protein tyrosine kinases, associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and interferon-alpha and beta (1-3). Following ligand binding, Tyk2 is activated by phosphorylation on Tyr1054 and/or Tyr1055 (4). Tyk2 is required for the tyrosine phosphorylation of Stat3 in the IFN-beta signaling cascade (5).
- Velazquez, L. et al. (1995) J. Biol. Chem. 270, 3327-3334.
- Stahl, N. et al. (1994) Science 263, 92-95.
- Leonard, W.J. (1998) Annu. Rev. Immunol. 16, 293-322.
- Grauzzi, M.C. et al. (1996) J. Biol. Chem. 271, 20494-20500.
- Rani, M.R. et al. (1999) J. Biol. Chem. 274, 32507-32511.
- Fiedler, J. et al. (2012) Haematologica 97, 73-81. Applications: Western Blotting
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For Research Use Only. Not For Use In Diagnostic Procedures.