Product Pathways - Apoptosis
Cleaved Drosophila ICE (drICE) (Asp230) Antibody #9478
|9478S||100 µl (10 western blots)||---||In Stock||---|
|9478||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
Cleaved Drosophila ICE (drICE) (Asp230) Antibody recognizes endogenous levels of the large 21 kDa fragment of cleaved drICE. This antibody also detects low levels of full length drICE (35 kDa).
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino-terminal residues adjacent to Asp230 of Drosophila ICE protein. Antibodies are purified by protein A and peptide affinity chromatography.
Cell death in the fruit fly Drosophila melanogaster is regulated by many of the same stimuli as mammalian cell death (1). The Drosophila genome contains seven caspase genes; three encode initiator caspases and four encode effector caspases (reviewed in 2). drICE is a cysteine protease that cleaves baculovirus p35 and lamin DmO in vitro and acts downstream of rpr (3). drICE is proteolytically processed during apoptosis into active p21 and p12 subunits. Comparison of the in vivo activity between drICE and Dcp-1 has shown that drICE is a more effective inducer of apoptosis than Dcp-1, which plays a role in determining the rate of cell death (4).
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