Product Pathways - Translational Control
Ribosomal Protein S3 (D50G7) XP® Rabbit mAb #9538
|W IP IF-IC||H M R Mk||Endogenous||27||Rabbit IgG|
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
Ribosomal Protein S3 (D50G7) XP® Rabbit mAb detects endogenous levels of total ribosomal protein S3.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human ribosomal protein S3.
Western blot analysis of extracts from various cell types using Ribosomal Protein S3 (D50G7) XP® Rabbit mAb.
Ribosomal protein S3 (rpS3) is a component of the 40S ribosomal subunit and is involved in translation. HSP90 interacts with both the amino-terminus and carboxy-terminus of rpS3, preventing its ubiquitination and degradation and thereby retaining the integrity of the ribosome (1). rpS3 has also been shown to function as an endonuclease during DNA damage repair (2,3). Furthermore, overexpression of rpS3 sensitizes lymphocytic cells to cytokine-induced apoptosis, indicating a third role for rpS3 during apoptosis (4). The functions of rpS3 during DNA damage repair and apoptosis have been mapped to two distinct domains (4).
- Kim, T.S. et al. (2006) Mol Biol Cell 17, 824-33.
- Kim, J. et al. (1995) J Biol Chem 270, 13620-9.
- Choi, S.H. et al. (2006) FEBS Lett 580, 6755-62.
- Jang, C.Y. et al. (2004) FEBS Lett 560, 81-5.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
- 2579 Ribosomal Protein S3 Antibody
- 2415 Ribosomal Protein L7a (E109) Antibody
- 2403 Ribosomal Protein L7a (R225) Antibody
- 4858 Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP® Rabbit mAb
- 9918 Translational Control Antibody Sampler Kit
- 2211 Phospho-S6 Ribosomal Protein (Ser235/236) Antibody
- 4851 Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate)
- 2215 Phospho-S6 Ribosomal Protein (Ser240/244) Antibody
- 2317 S6 Ribosomal Protein (54D2) Mouse mAb
- 9997 Tris Buffered Saline with Tween 20 (TBST-10X)
- 9998 BSA
- 9999 Nonfat Dry Milk
- 7071 Phototope®-HRP Western Blot Detection System, Anti-rabbit IgG, HRP-linked Antibody
- 7074 Anti-rabbit IgG, HRP-linked Antibody
- 7720 Prestained Protein Marker, Broad Range (Premixed Format)
- 7727 Biotinylated Protein Ladder Detection Pack
- 7003 20X LumiGLO® Reagent and 20X Peroxide
For Research Use Only. Not For Use In Diagnostic Procedures.