Product Pathways - Apoptosis
- Molecular Formula:
- Molecular Weight:
- 466.53 g/mol
Directions for Use
Dissolve the lyophilized alkaloid in DMSO or Methanol. For a 1 mM solution, dissolve in 0.536 mL.
Staurosporine is an alkaloid isolated from the culture broth of Streptomyces staurosporesa. It is a potent, cell permeable protein kinase C inhibitor with an IC50 of 0.7 nM. At higher concentration (1-20 nM), staurosporine also inhibits other kinases such as PKA, PKG, CAMKII and Myosin light chain kinase (MLCK) (1). At 50-100 nM, it is a functional neurotrophin agonist, promoting neurite outgrowth in neuroblastoma, pheochromocytoma and brain primary neuronal cultures. At 0.2- 1 μM, staurosporine induces cell apoptosis (2,3).
- Ruegg, U.T. and Burgess, G.M. (1989) Trends Pharmacol. Sci. 10, 218-220.
- Couldwell , W. T. et al. (1994) FEBS Lett. 345, 43-46.
- Yue, T. L. et al. (1998) J. Mol. Cell. Cardiol. 30, 495-507.
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For Research Use Only. Not For Use In Diagnostic Procedures.