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9905
TPA (Phorbol-12-Myristate-13-Acetate)
Activators & Inhibitors
Chemical Modulators

TPA (Phorbol-12-Myristate-13-Acetate) #9905

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Product Usage Information

TPA is supplied as a 200 μM stock in DMSO. For standard 200 nM treatment, dilute 1000X.

Storage

Store lyophilized or in solution at -20°C. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency.

Product Description

TPA (12-O-tetradecanoylphorbol-13-acetate) / PMA (phorbol-12-myristate-13-acetate) is soluble in DMSO and ethanol. DMSO solutions can be stored at -20ºC, in the absence of light, for at least six months. A 200 nM TPA treatment is standard to induce signaling.
MW (kDa) 616.84

Background

TPA (12-O-tetradecanoylphorbol-13-acetate) / PMA (phorbol-12-myristate-13-acetate) is the most commonly used phorbol ester. It binds and activates protein kinase C, causing a wide range of effects in cells and tissues (1,2). TPA has been demonstrated to be a potent tumor promoter in mouse skin (3). Conversely, it has been shown to be an effective cancer therapeutic agent in myelocytic leukemia patients, and has been indicated as a potential colorectal cancer therapeutic (4-5). TPA has also been shown to increase white blood cell and neutrophil counts in solid tumor cancer patients (6).

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.
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