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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

SYVN1 Antibody recognizes endogenous levels of total synoviolin-1 protein. This antibody does not cross-react with AMFR/gp78.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human synoviolin-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Synoviolin-1 (SYVN1/HRD1) is a RING-type E3 ubiquitin-protein ligase and major component of the endoplasmic reticulum (ER) quality control system that is involved in the ubiquitin-dependent degradation of misfolded proteins (1). SYVN1 is a multispanning ER membrane protein whose expression is upregulated at the protein level under conditions that promote ER stress (1-4). Research studies have shown that SYVN1 is an anti-apoptotic factor that is implicated in the pathogenesis of arthropathy by promoting synovial hyperplasia (5). Furthermore, gene-targeting studies have demonstrated that SYVN1 expression is indispensable for embryogenesis (6).

1.  Kikkert, M. et al. (2004) J Biol Chem 279, 3525-34.

2.  Kaneko, M. et al. (2007) FEBS Lett 581, 5355-60.

3.  Yamamoto, K. et al. (2008) J Biochem 144, 477-86.

4.  Nadav, E. et al. (2003) Biochem Biophys Res Commun 303, 91-7.

5.  Amano, T. et al. (2003) Genes Dev 17, 2436-49.

6.  Yagishita, N. et al. (2005) J Biol Chem 280, 7909-16.

Entrez-Gene Id 84447
Swiss-Prot Acc. Q86TM6

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

SYVN1 Antibody