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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Vti1a Antibody recognizes endogenous levels of total Vti1a protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu126 of human Vti1a protein. Antibodies are purified by protein A and peptide affinity chromatography.

Vesicle transport through interaction with t-SNAREs homolog 1 (Vti1) has two protein members, Vti1a and Vti1b. Human Vti1 was first identified as a homolog of the yeast v-SNARE Vti1p and was able to functionally rescue the phenotype of Vti1p-deficient yeast (1). The mammalian proteins Vti1a and Vti1b exhibit distinct but overlapping localization. Vti1a and Vti1b are both localized in the trans-Golgi network, with Vti1a also found in the Golgi apparatus and Vti1b in endosomes (2). Vti1 proteins have been implicated in a number of protein-protein interactions with partners such as VAMP4, syntaxin 6, syntaxin 8, syntaxin 16, and synaptobrevin (2-4).

Vti1a that resides on synaptic vesicles has been shown to be involved in maintaining spontaneous neurotransmitter release (5).

1.  Fischer von Mollard, G. and Stevens, T.H. (1998) J Biol Chem 273, 2624-30.

2.  Kreykenbohm, V. et al. (2002) Eur J Cell Biol 81, 273-80.

3.  Antonin, W. et al. (2000) J Neurosci 20, 5724-32.

4.  Atlashkin, V. et al. (2003) Mol Cell Biol 23, 5198-207.

5.  Ramirez, D.M. et al. (2012) Neuron 73, 121-34.

Entrez-Gene Id 143187
Swiss-Prot Acc. Q96AJ9

For Research Use Only. Not For Use In Diagnostic Procedures.
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