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21 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

VIMP Antibody recognizes endogenous levels of total VIMP protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human VIMP protein. Antibodies are purified by protein A and peptide affinity chromatography.

VCP-interacting membrane protein (VIMP, selenoprotein S) is a putative reductase and endoplasmic reticulum (ER)-resident protein involved in the ER-associated degradation (ERAD) pathway (1,2). Research studies indicate that VIMP may play a protective role against inflammation and reduce ER-stress (3). The VIMP protein is a single-pass, transmembrane protein that recruits the cytosolic p97/VCP AAA-ATPase and its cofactors, UFD1 and NPL4, to the ER membrane (4). An ER membrane complex containing Derlin-1 and VIMP forms a critical node in the ERAD machinery and links substrate recognition in the ER lumen with the retrotranslocation function of the p97/VCP AAA-ATPase in the cytosol (1,4). Polymorphisms in the corresponding VIMP gene are associated with spontaneous preterm births and cardiovascular disease risk (5,6) while other studies do not support a correspondence between VIMP polymorphisms and inflammatory disorders (7).

1.  Christensen, L.C. et al. (2012) J Biol Chem 287, 26388-99.

2.  Fradejas, N. et al. (2011) Glia 59, 959-72.

3.  Ye, Y. et al. (2004) Nature 429, 841-7.

4.  Lilley, B.N. and Ploegh, H.L. (2005) Proc Natl Acad Sci USA 102, 14296-301.

5.  Wang, Y. et al. (2013) PLoS One 8, e65657.

6.  Cox, A.J. et al. (2013) Acta Diabetol 50, 391-9.

7.  Martínez, A. et al. (2008) BMC Genomics 9, 329.

Entrez-Gene Id 55829
Swiss-Prot Acc. Q9BQE4

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VIMP Antibody