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50 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

TAZ Antibody detects endogenous levels of total TAZ protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids surrounding Ala200 of mouse TAZ. Antibodies are purified by protein A and peptide affinity chromatography.

TAZ is a transcriptional co-activator with a PDZ-binding motif that is regulated by its interaction with 14-3-3 proteins (1). TAZ shares homology with the WW domain of Yes-associated protein (YAP) (1). TAZ is proposed to modulate the switch between proliferation and differentiation of mesenchymal stem cells (MSC) via interaction with transcription factors Runx2 and PPARγ. This process is critical to normal tissue development and the prevention of tumor formation. Due to its role in determination of MSC fate, TAZ may have clinical relevance to several human diseases caused by an imbalance of MSC differentiation (2,3). TAZ is negatively regulated via phosphorylation by LATS1/2, core kinases in the Hippo signaling pathway that controls stem cell development, tissue growth and tumor development (4).

1.  Kanai, F. et al. (2000) EMBO J 19, 6778-91.

2.  Hong, J.H. et al. (2005) Science 309, 1074-8.

3.  Hong, J.H. and Yaffe, M.B. (2006) Cell Cycle 5, 176-9.

4.  Lei, Q.Y. et al. (2008) Mol Cell Biol 28, 2426-36.

Entrez-Gene Id 25937
Swiss-Prot Acc. Q9GZV5

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

TAZ Antibody