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30 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Emerin (A212) Antibody detects endogenous levels of total Emerin protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala212 of human Emerin. Antibodies are purified by peptide affinity chromatography.

Emerin is a broadly expressed integral protein of the nuclear inner membrane (1). It contains a LEM domain and binds to several nuclear proteins, such as BAF (barrier-to-autointegration factor) and A- and B-type lamins, which are important in nuclear functions (2-5). Emerin may regulate gene expression through binding to other transcriptional regulators (6,7). Emerin binds to β-catenin and inhibits its nuclear accumulation (8). Recent studies demonstrate that Emerin is required for HIV-1 infectivity (9). Mutations in Emerin are a major cause of Emery-Dreifuss muscular dystrophy (EDMD), a disorder characterized by progressive skeletal muscle weakening (10).

1.  Nagano, A. et al. (1996) Nat. Genet. 12, 254-259.

2.  Manilal, S. et al. (1998) Biochem. Biophys. Res. Commun. 249, 643-647.

3.  Clements, L. et al. (2000) Biochem. Biophys. Res. Commun. 267, 709-714.

4.  Lee, K.K. et al. (2001) J. Cell Sci. 114, 4567-4573.

5.  Bengtsson, L. and Wilson, K.L. (2006) Mol. Biol. Cell 17, 1154-1163.

6.  Holaska, J.M. et al. (2003) J. Biol. Chem. 278, 6969-6975.

7.  Haraguchi, T. et al. (2004) Eur. J. Biochem. 271, 1035-1045.

8.  Markiewicz, E. et al. (2006) EMBO J. 25, 3275-3285.

9.  Jacque, J.M. and Stevenson, M. (2006) Nature 441, 641-645.

10.  Holaska, J.M. and Wilson, K.L. (2006) Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 288, 676-680.

Entrez-Gene Id 2010
Swiss-Prot Acc. P50402

For Research Use Only. Not For Use In Diagnostic Procedures.
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Emerin (A212) Antibody