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M R Endogenous 42 Rabbit

Western blot analysis of extracts from various cell types using THEX1 Antibody.

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Product Usage Information

Application Dilutions
Western Blotting 1:1000
Immunoprecipitation 1:50

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

THEX1 Antibody detects endogenous levels of total THEX1 protein.

Species Reactivity: Mouse, Rat

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of mouse THEX1. Antibodies are purified by protein A and peptide affinity chromatography.

THEX1 (3’hExo) is a 3’ exonuclease that may play a role in the degradation of histone mRNA transcripts (1). A recently identified member of the DEDDh 3' exonuclease family, THEX1 binds the conserved stem-loop structure found at the 3’ end of mRNA in vitro (2). The binding of THEX1 to mRNA requires the presence of a terminal ACCCA sequence and is enhanced by the concurrent binding of stem-loop binding protein (SLBP). Cleavage of histone mRNA by THEX1 exonuclease may help produce the rapid turnover of histone mRNA transcripts associated with the completion of DNA replication (3). Additional evidence suggests that THEX1 may be responsible for excising the remaining few 3’ nucleotides following cleavage by a different enzyme (4).

1.  Dominski, Z. and Marzluff, W.F. (1999) Gene 239, 1-14.

2.  Dominski, Z. et al. (2003) Mol Cell 12, 295-305.

3.  Yang, X.C. et al. (2006) J Biol Chem 281, 30447-54.

4.  Mullen, T.E. and Marzluff, W.F. (2008) Genes Dev 22, 50-65.

Entrez-Gene Id 90459
Swiss-Prot Acc. Q8IV48

For Research Use Only. Not For Use In Diagnostic Procedures.
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