Upstream / Downstream

pathwayImage

Explore pathways related to this product.

Our U.S. Offices Will Be Closing Early

Our U.S. offices will be closing early on November 26th at 6:00 PM EST.

To get local purchase information on this product, click here

Questions?

Find answers on our FAQs page.

ANSWERS  

Visit PhosphoSitePlus®

PTM information and tools available.

LEARN MORE

Product Includes Quantity Applications Reactivity MW(kDa) Isotype
Integrin α5 Antibody 4705 40 µl
Western Blotting
H M Mk 150 Rabbit 
Integrin αV Antibody 4711 40 µl
Western Blotting Immunoprecipitation
H R 135, 140 Rabbit 
Integrin β4 Antibody 4707 40 µl
Western Blotting
H 210 Rabbit 
Integrin α4 (D2E1) XP® Rabbit mAb 8440 40 µl
Western Blotting Immunoprecipitation Immunofluorescence Flow Cytometry
H M R 70, 140, 150, Rabbit 
Integrin β1 (D2E5) Rabbit mAb 9699 40 µl
Western Blotting Immunohistochemistry
H 115, 135 Rabbit IgG
Integrin β3 (D7X3P) XP® Rabbit mAb 13166 40 µl
Western Blotting Immunohistochemistry
H M 100 Rabbit IgG
Integrin beta-5 (D24A5) Rabbit mAb 3629 40 µl
Western Blotting Immunoprecipitation Immunofluorescence
H M R Mk 90 Rabbit IgG
Anti-rabbit IgG, HRP-linked Antibody 7074 100 µl
Western Blotting
All Goat 

Product Description

The Integrin Antibody Sampler Kit provides an economical means to screen samples for α and β subunits of integrin molecules. The kit includes enough primary and secondary antibody to perform four Western blot experiments with each antibody.


Specificity / Sensitivity

All antibodies in the Integrin Antibody Sampler Kit detect endogenous levels of their target α and β integrin subunits of the integrin dimer. None of the antibodies provided detect intact dimers or their activational state.


Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser458 of human integrin α5 protein, Arg108 of human integrin αV, and Ser1812 of human integrin β4 protein. Antibodies are purified by protein A and peptide affinity chromatography. Monoclonal antibodies are produced by immunizing animals with a synthetic peptide sequence corresponding to residues surrounding Ser1027 of human integrin α4 protein, Pro680 of human integrin β1 protein, Ile114 of human integrin β3 protein, and Lys789 of human β5 protein.

Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2).


1.  Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100.

2.  Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71.

3.  van der Flier, A. and Sonnenberg, A. (2001) Cell Tissue Res 305, 285-98.


Entrez-Gene Id 3685, 3676, 3688, 3690, 3691, 3693, 3678
Swiss-Prot Acc. P06756, P13612, P05556, P05106, P16144, P18084, P08648


For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.