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Product Includes Quantity Applications Reactivity MW(kDa) Isotype
Phospho-LKB1 (Ser428) (C67A3) Rabbit mAb 3482 100 µl
H M R Mk 54 Rabbit 
LKB1 (D60C5) Rabbit mAb 3047 100 µl
H M R Mk 54 Rabbit IgG

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Product Description

PhosphoPlus® Duets from Cell Signaling Technology (CST) provide a means to assess protein activation status. Each Duet contains an activation-state and total protein antibody to your target of interest. These antibodies have been selected from CST's product offering based upon superior performance in specified applications.


LKB1 (STK11) is a serine/threonine kinase and tumor suppressor that helps control cell structure, apoptosis and energy homeostasis through regulation of numerous downstream kinases (1,2). A cytosolic protein complex comprised of LKB1, putative kinase STRAD, and the MO25 scaffold protein, activates both AMP-activated protein kinase (AMPK) and several AMPK-related kinases (3). AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations (4). LKB1 appears to be phosphorylated in cells at several sites, including human LKB1 at Ser31/325/428 and Thr189/336/363 (5).

Mutation in the corresponding LKB1 gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands, and feet (6). A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues (7).


1.  Baas, A.F. et al. (2004) Trends Cell Biol 14, 312-9.

2.  Marignani, P.A. (2005) J Clin Pathol 58, 15-9.

3.  Lizcano, J.M. et al. (2004) EMBO J 23, 833-43.

4.  Hardie, D.G. (2004) J Cell Sci 117, 5479-87.

5.  Sapkota, G.P. et al. (2002) Biochem J 362, 481-90.

6.  Jenne, D.E. et al. (1998) Nat Genet 18, 38-43.

7.  Sanchez-Cespedes, M. (2007) Oncogene 26, 7825-32.


Entrez-Gene Id 6794
Swiss-Prot Acc. Q15831


For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
PhosphoPlus® is a trademark of Cell Signaling Technology, Inc.
U.S. Patent No. 5,675,063.