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105 Rabbit 

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CASK (D14E3) Rabbit mAb recognizes endogenous levels of total CASK protein. This antibody also detects a background band of unknown origin at 75 kDa.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly233 of human CASK protein.

CASK is an adaptor protein with a calcium/calmodulin-dependent protein kinase domain, an SH3 domain, a guanylate kinase homology domain (GUK), and a PDZ domain. CASK links transmembrane proteins to the cytoskeleton and signaling molecules. In particular, CASK binds to neurexin to stabilize pre- and post-synaptic structures (1). While most CASK protein (~80%) is cytoplasmic, a portion of the protein enters the nucleus, where it acts as a transcriptional coactivator (2). Transgenic mice with CASK insertional mutations die within 24 hours of birth (3).

1.  Hata, Y. et al. (1996) J Neurosci 16, 2488-94.

2.  Hsueh, Y.P. et al. (2000) Nature 404, 298-302.

3.  Laverty, H.G. and Wilson, J.B. (1998) Genomics 53, 29-41.

Entrez-Gene Id 8573
Swiss-Prot Acc. O14936

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

CASK (D14E3) Rabbit mAb