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Product Includes Quantity Applications Reactivity MW(kDa) Isotype
Keratin 17 (D73C7) Rabbit mAb 4543 40 µl
Western Blotting Immunofluorescence Flow Cytometry
H M R 48 Rabbit IgG
Keratin 8/18 (C51) Mouse mAb 4546 40 µl
Western Blotting Immunohistochemistry Immunofluorescence Flow Cytometry
H Mk 46 Keratin 18. 55 Keratin 8. Mouse IgG1
Keratin 18 (DC10) Mouse mAb 4548 40 µl
Western Blotting Immunohistochemistry Immunofluorescence Flow Cytometry
H 46 Mouse IgG1
Keratin 19 (BA17) Mouse mAb 4558 40 µl
Western Blotting Immunohistochemistry
H 40 Mouse IgG1
Pan-Keratin (C11) Mouse mAb 4545 40 µl
Western Blotting Immunohistochemistry Immunofluorescence Flow Cytometry
H R Mk 46-58 Mouse IgG1
Keratin 7 (D1E4) XP® Rabbit mAb 4465 40 µl
Western Blotting Immunofluorescence Flow Cytometry
H 52 Rabbit IgG
Anti-mouse IgG, HRP-linked Antibody 7076 100 µl
Western Blotting
All Horse 
Anti-rabbit IgG, HRP-linked Antibody 7074 100 µl
Western Blotting
All Goat 

Product Description

The Cytokeratin Antibody Sampler Kit provides an economical means to evaluate the presence and status of selected keratin proteins. The kit provides enough primary and secondary antibodies to perform four Western blot experiments per primary antibody.


Specificity / Sensitivity

The pan-keratin (C11) mouse mAb detects endogenous levels of total keratins 4, 5, 6, 8, 10, 13 and 18. The antibody does not cross-react with other keratins. Each of the remaining antibodies included in this kit detect endogenous levels of the specified keratin protein and do not cross-react with other keratin proteins.


Source / Purification

Pan-Keratin Mouse mAb (C11) is produced by immunizing animals with a cytoskeleton preparation from A431 cells. Keratin 8/18 (C51) Mouse mAb is produced by immunizing animals with a cytoskeleton preparation from HeLa cells. Keratin 18 (DC10) Mouse mAb is produced by immunizing animals with human PMC-42 breast carcinoma cells. Keratin 19 (BA17) Mouse mAb is produced by immunizing animals with detergent-insoluble extract of human mammary epithelial organoids. Keratin 7 (D1E4) XP® Rabbit mAb is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human keratin 7 protein and Keratin 17 (D73C7) XP® Rabbit mAb is produced by immunizing animals with a synthetic peptide corresponding to amino acids near the carboxy terminus of human keratin 17

Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers (1). Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).


1.  Moll, R. et al. (1982) Cell 31, 11-24.

2.  Chang, L. and Goldman, R.D. (2004) Nat Rev Mol Cell Biol 5, 601-13.

3.  Ramaekers, F.C. and Bosman, F.T. (2004) J Pathol 204, 351-4.

4.  Lane, E.B. and McLean, W.H. (2004) J Pathol 204, 355-66.

5.  Zatloukal, K. et al. (2004) J Pathol 204, 367-76.

6.  Owens, D.W. and Lane, E.B. (2004) J Pathol 204, 377-85.


Entrez-Gene Id 3872, 3875, 3853, 3854, 3858, 3860, 3880, 3851, 3852, 286887, 3855, 3856
Swiss-Prot Acc. Q04695, P05783, P02538, P04259, P13645, P13646, P08727, P19013, P13647, P48668, P08729, P05787


For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.