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PTEN (D4.3) XP® Rabbit mAb (Sepharose® Bead Conjugate) #4326
Gallery: PTEN (D4.3) XP® Rabbit mAb (Sepharose® Bead Conjugate) #4326
PTEN (D4.3) XP® Rabbit mAb (Sepharose® Bead Conjugate) detects endogenous levels of total PTEN protein.Species Reactivity: Human, Mouse, Rat, Monkey, Dog Species predicted to react based on 100% sequence homology: Chicken
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues in the carboxy-terminal sequence of human PTEN.
This Cell Signaling Technology antibody is immobilized via covalent binding of primary amino groups to N-hydroxysuccinimide (NHS)-activated Sepharose® beads. PTEN (D4.3) XP® Rabbit mAb (Sepharose® Bead Conjugate) is useful for the immunoprecipitation of PTEN protein.
PTEN (phosphatase and tensin homologue deleted on chromosome ten), also referred to as MMAC (mutated in multiple advanced cancers) phosphatase, is a tumor suppressor implicated in a wide variety of human cancers (1). PTEN encodes a 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase (2). The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3-kinase (PI3K) (3). PTEN is a major negative regulator of the PI3K/Akt signaling pathway (1,4,5). PTEN possesses a carboxy-terminal, noncatalytic regulatory domain with three phosphorylation sites (Ser380, Thr382, and Thr383) that regulate PTEN stability and may affect its biological activity (6,7). PTEN regulates p53 protein levels and activity (8) and is involved in G protein-coupled signaling during chemotaxis (9,10).
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc. XP is a registered trademark of Cell Signaling Technology, Inc.