BRCT Domain
The C-terminal BRCT domain of XRCC1.
Domain Binding and Function
The BRCT domain (BRCA1 C-terminus) is a conserved protein—protein interaction region of approximately 95 amino acids found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. It was first identified in the breast cancer suppressor protein BRCA1 but is also found in DNA repair proteins such as DNA ligase III and XRCC1, which form strong heterodimers through their BRCT domains. The C-terminal BRCT domain of BRCA1 has been reported to bind to the central domain of p53, allowing BRCA1 to act as a coactivator of p53.
Structure Reference
- Zhang, X. et al. (1998) EMBO J. 17(21), 6404–6411.
Examples of Domain Proteins
Binding Examples
| BRCT Domain Proteins | Binding Partners | Domain Binding Sites |
|---|---|---|
| DNA Ligase III | XRCC1 | BRCT domain heterodimerization |
| BRCA1 | p53 | Central domain of p53 |
| PTIP | Pax2 | |
| TopBP1 | DNA | Single strand breaks and termini |
