GYF Domain

Domain Binding and Function

The glycine-tyrosine-phenylalanine, or GYF domain was first reported in the CD2 binding protein CDBP2 as a domain capable of binding to a proline-rich peptide sequence in the CD2 tail region. Despite functioning as a proline-rich peptide binding domain, the GYF fold is structurally unrelated to the SH3 or WW domains. The GYF domain of CDBP2 binds to a PPPPGHR repeat in the CD2 tail via a relatively smooth, concave surface that forms a continuous hydrophobic patch containing many of the GYF domain—conserved residues.

Structure Reference

1. Freund, C. et al. (1999) Nat. Struct. Biol. 6, 656–660.

Examples of Domain Proteins

Binding Examples

GYF Domain Proteins	Binding Partners	GYF Domain Binding Sites
CDBP2	CD2	PPPPGHR