PB1 Domain
The PB1 domain from yeast Bem1.
Domain Binding and Function
Phox and Bem1 (PB1) domains contain approximately 80 amino acids and are found in a number of cytoplasmic signaling proteins. The PB1 domain is involved in the heterodimerization with a paired PB1 domain, although not all PB1 domains will associate with one another. A highly conserved internal sequence known as OPR, PC or AID motifs is necessary for PB1 domain function. Regions outside the OPR, PC and AID help confer specificity for binding.
Structure Reference
- Terasawa, H. et al., (2002) EMBO 20(15), 3947–3956.
Examples of Domain Proteins
Binding Examples
| PB1 Domain Proteins | Binding Partners |
|---|---|
| Par-6 isoforms | PKCζ, PKCι/λ |
| Bem1 | Cdc24 |
| p67phox | p40phox |
