Cell Signaling Technology

SAM Domain

The SAM domain from the EphA4 receptor.

Domain Binding and Function

The approximately 70 amino acid SAM (Sterile α Motif) domain has been identified in over 400 different proteins with diverse cellular function, from yeast to man. SAM domains have been implicated in mediating protein—protein interaction via the formation of homo- and heterotypic oligomers. The residues at the interface of the EphA4 and EphB2 SAM domain homodimers have been mapped, but the factors that determine specificity remain to be determined.

Structure Reference

  1. Stapleton, D. et al. (1999) Nat. Struct. Biol. 6(1), 44–49.

Examples of Domain Proteins

Binding Examples

SAM Domain Proteins Binding Partners
Polycomb group chromatin remodeling proteins:
Scm Homotypic and heterotypic interactions
Ph Homotypic and heterotypic interactions
Rae 28 Homotypic and heterotypic interactions
Ste11 Yeast MAPKKK Ste50
Tel ETS Family Transcription Factor Tel

Reference