SAM Domain
The SAM domain from the EphA4 receptor.
Domain Binding and Function
The approximately 70 amino acid SAM (Sterile α Motif) domain has been identified in over 400 different proteins with diverse cellular function, from yeast to man. SAM domains have been implicated in mediating protein—protein interaction via the formation of homo- and heterotypic oligomers. The residues at the interface of the EphA4 and EphB2 SAM domain homodimers have been mapped, but the factors that determine specificity remain to be determined.
Structure Reference
- Stapleton, D. et al. (1999) Nat. Struct. Biol. 6(1), 44–49.
Examples of Domain Proteins
Binding Examples
| SAM Domain Proteins | Binding Partners |
|---|---|
| Polycomb group chromatin remodeling proteins: | |
| Scm | Homotypic and heterotypic interactions |
| Ph | Homotypic and heterotypic interactions |
| Rae 28 | Homotypic and heterotypic interactions |
| Ste11 Yeast MAPKKK | Ste50 |
| Tel ETS Family Transcription Factor | Tel |
