Phospho-Ser/Thr Binding: WD40 Domain
The WD40 repeats in G β.
Domain Binding and Function
WD40 repeats are found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing, cytoskeleton assembly and cell cycle control. The only common functional theme of WD40 domains is to serve as a stable propeller-like platform to which proteins can bind either stably or reversibly. Unlike the non-WD40 propeller family of proteins, there are no cases of WD40 proteins with catalytic activity. The WD40 domains of β-TRCP and Cdc4 have been implicated in recognizing phosphorylated serine and threonine containing peptides, demonstrating that in some cases WD40 repeat forming β-propeller structures can serve in phospho-peptide recognition.
Structure Reference
- Wall, M.A. et al. (1995) Cell 83(6), 1047–1058.
Examples of Domain Proteins
Binding Examples
| WD40 Domain Proteins | Binding Partners | Functions |
|---|---|---|
| G-Protein β-Chain | G-protein α,γ-chain | Signal transduction |
| Prp4 Splicing Factor | Prp3 Splicing Factor | Splicing |
| Tup1 Transcriptional Repressor | α2 Transcriptional repressor | Transcription |
| Cdc4 | phosphorylated Sic1 | Ubiquitination and Cell Cycle control |
