Pro-rich Sequence Binding: WW Domain
WW domain of Pin1 bound to a doubly phosphorylated peptide.
Domain Binding and Function
WW domains are small, 38 to 40 amino acid residue modules implicated in binding to Pro-rich sequences. WW domains and SH3 domains can potentially bind overlapping sites. In addition, the Pin1 WW domain functions as a phosphoserine or phosphothreonine binding module, suggesting that certain WW domains have evolved an alternate mode of action. WW domains bind peptide ligands with dissociation constants in the µM range.
- Verdecia, M.A. et al. (2000) Nat. Struc. Biol. 7(8) 639–643.
Examples of Domain Proteins
|WW Domain Proteins||Binding Partners||WW Domain Binding Sites|
|Yes-Associated Protein (YAP)||Yes, Src-like Tyrosine Kinase||PPPPY|
|Nedd4 E3 Ubiquitin Ligase||ΒENaC amiloride-E3 ubiquitin ligase-sensitive epithelial Na+ channel||PPPNY|