Cell Signaling Technology

Cellular Landscapes: Mitochondria

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Molecular landscape depicting key signaling proteins in apoptosis (upper right), ubiquitin-mediated protein degradation (bottom half) and Warburg (upper left and mitochondrion) pathways. Structural data derived from the PDB and/or EMDB and modeled with Molecular Maya (mMaya).

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Mitochondria Landscape Mitochondria apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome apoptosome bak bak bak bak bax bax bax bax bax bax bax bax bax bax bax bax bax bax bax bax bax bax bax bcl2 bcl2 bcl2 bcl2 bcl2 bcl2 bclxl bid bid caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase3 caspase9 caspase9 caspase9 caspase9 caspase9 caspase9 caspase9 caspase9 caspase9 caspase9 caspase9 gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin gelsolin vdac1 vdac1 vdac1 vdac1 actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin actin fascin fascin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin tubulin atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth atpSynth complex1 complex1 complex1 complex1 complex1 complex1 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 complex2 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytBC1 cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cytochromeC cct cct cct cct cct cct cct cct cct cct cct cct cct cct cct cct cct cct cct cct cct hsp60 hsp60 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp70 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 hsp90 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 sba1 smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP smHSP aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase aconitase akgd akgd akgd akgd akgd akgd akgd akgd cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth cytrateSynth fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd fumarateHyd idh idh idh idh idh idh idh idh idh idh idh idh idh idh idh idh malateDeh malateDeh malateDeh malateDeh malateDeh malateDeh malateDeh malateDeh succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA succ_coA membrane_mito membrane_mito membrane_mito membrane_mito membrane_mito membrane_mito membrane_mito membrane_mito membrane_mito membrane_nuclear membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membrane_vesicles membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae membranes_cristae dnaPolGamma dnaPolGamma dnaPolGamma dnaPolGamma dnaPolGamma dnaPolGamma dnaPolGamma dnaPolGamma mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoDNA mitoRNAPol mitoRNAPol mitoRNAPol mitoRNAPol mitoRNAPol mitoRNAPol mitoRNAPol mitoRNAPol mitoRNAPol mitoRNAPol atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier atpAdpCarrier clpP clpP clpP clpP clpP clpP clpP clpP clpP clpP tim8-13 tim8-13 tim8-13 tim8-13 tim8-13 tim8-13 tim8-13 tim8-13 tim8-13 tim8-13 tim8-13 tim8-13 tim44 tim44 tim44 tim44 tim44 tim44 tim44 tim44 tim44 tim44 tim44 tim44 tim44 tim44 tim44 tom70 tom70 tom70 tom71 tom71 vdac1 vdac1 vdac1 vdac1 e1_ubiquitin e1_ubiquitin e1_ubiquitin e1_ubiquitin e1_ubiquitin e2_ubiquitin e2_ubiquitin e2_ubiquitin e2_ubiquitin e2_ubiquitin e2_ubiquitin e2_ubiquitin e3_ubiquitin e3_ubiquitin e3_ubiquitin e3_ubiquitin e3_ubiquitin e3_ubiquitin p53 p53 p53 p53 p53 p53 p53 p53 p53 p53 p53 p53 p53 p53 proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome proteasome tpp2 tpp2 tpp2 tpp2 tpp2 tpp2 tpp2 tpp2 tpp2 tpp2 tpp2 tpp2 ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin ubiquitin 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome 80Sribosome tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNA tRNAinitiator tRNAinitiator tRNAinitiator tRNAinitiator cop1 cop1 cop1 cop1 cop1 cop1 cop1 cop1 cop1 cop1 cop1 cop1 cop1 cop1 cop1 cop1 cop2 cop2 cop2 cop2 cop2 cop2 cop2 cop2 cop2 cop2 cop2 cop2 cop2 cop2 cop2 cop2 cop2 acl acl acl acl acl akt akt akt akt akt akt akt akt akt akt akt akt akt glutaminase glutaminase glutaminase glutaminase glutaminase glutaminase glutaminase hexokinase1 hexokinase1 hexokinase1 hexokinase1 hexokinase1 hexokinase1 hexokinase1 hexokinase1 hexokinase1 hexokinase1 hexokinase2 hexokinase2 hexokinase3 hexokinase3 hexokinase3 hexokinase3 hexokinase3 hexokinase3 hexokinase3 hexokinase3 ldh ldh ldh malicE malicE malicE malicE malicE malicE mcl1 mcl1 mcl1 mcl1 mcl1 mcl1 mcl1 mcl1 pdc pdc pdhk2 pdhk2 pdhk2 pdhk2 pdhk2 pdhk2 pdhk2 pdhk2 pdhk2 pdhk4 pdhk4 pdhk4 pdhk4 pdhk4 pdhk4 pdhk4 pdp pdp pdp pdp pdp pdp pdp pfk pfk pfk pfk pfk pyruvateCarb pyruvateCarb pyruvateCarb pyruvateCarb pyruvateCarb pyruvateCarb pyruvateCarb pyruvateK pyruvateK pyruvateK pyruvateK pyruvateK pyruvateK tigar tigar tigar acylCoAdeh acylCoAdeh acylCoAdeh acylCoAdeh acylCoAdeh acylCoAdeh acylCoAdeh acylCoAdeh acylCoAdeh acylCoAdeh acylCoAdeh acylCoAdeh acylCoAdeh acylCoAdeh adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK adenylateK cdk4 cdk4 cdk4 cdk4 cdk4 cdk4 cdk4 cdk4 cdk4 cdk4 cdk4 creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK creatineK cyclinD cyclinD cyclinD cyclinD cyclinD cyclinD exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin exportin gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh gdh importin importin importin importin importin importin importin importin importin importin importin importin mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 mago-Y14 maoB maoB maoB mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD mnSOD ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk ndpk npc npc npc oat oat oat oat oat oat oat oat oat oat oat oat oat oat oat RanGTP RanGTP RanGTP RanGTP RanGTP RanGTP RanGTP RanGTP RanGTP RanGTP RanGTP grey background apoptosis apoptosome bak bax bcl2 bclxl bid caspase3 caspase9 cytochromeC gelsolin vdac1 actin cytoskeleton fascin tubulin atpSynth complex1 complex2 cytBC1 cytochromeC elecTrans hsp cct hsp60 hsp70 hsp90 sba1 smHSP aconitase akgd cytrateSynth fumarateHyd idh krebs malateDeh succ_coA membrane membrane_mito membrane_nuclear membrane_vesicles membranes_cristae dnaPolGamma mitoDNA mitoDNA mitoGenetics mitoRNAPol atpAdpCarrier clpP mitoImportExport tim8-13 tim44 tom70 tom71 vdac1 e1_ubiquitin e2_ubiquitin e3_ubiquitin p53 proteasome proteolysis tpp2 ubiquitin 80Sribosome translation tRNA tRNAinitiator cop1 cop2 vesicleTrafficking acl akt glutaminase hexokinase1 hexokinase2 hexokinase3 ldh malicE mcl1 pc pdc pdhk2 pdhk4 pdp pfk pyruvateK tigar warburg acylCoAdeh adenylateK cdk4 creatineK cyclinD exportin gdh importin mago-Y14 maoB mnSOD ndpk npc oat RanGTP

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