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Human Oncogenes & Tumor Suppressor Genes

Enumerates known oncogenes and tumor suppressors, with corresponding genetic alterations and cellular effects.

Akt Signaling Pathway

  Protein Genetic
Alterations		 Evading
Apoptosis		 Self-Suffciency
in Growth Status		 Insensitivity to
Anti-Growth Signals		 Tissue Invasion
& Metastasis		 Sustained
Angiogenesis
Oncogenes Symbol Akt Point mutation, amplification, increased expression Indicates Protein Features        
Oncogenes Symbol Bax Point mutation Indicates Protein Features        
Oncogenes Symbol FKHR/FoxO Translocation Indicates Protein Features        
Tumor Suppressor Symbol PI3K Point mutation Indicates Protein Features        
Tumor Suppressor Symbol Bcl2 Translocation Indicates Protein Features        
Tumor Suppressor Symbol INPP4B Deletion, loss of heterozygosity, reduced expression          
Tumor Suppressor Symbol LKB1 Point mutation   Indicates Protein Features     Indicates Protein Features
Tumor Suppressor Symbol PTEN Point mutation, deletion Indicates Protein Features        
Tumor Suppressor Symbol TSC1/TSC2 Point mutation   Indicates Protein Features      
Table Key:  Oncogenes Tumor Suppressor Symbol Tumor Suppressors Indicates Protein FeaturesIndicates Protein Function

Cell Cycle Control: G1/S Checkpoint

  Protein Genetic
Alterations		 Evading
Apoptosis		 Self-Suffciency
in Growth Status		 Insensitivity to
Anti-Growth Signals		 Tissue Invasion
& Metastasis		 Sustained
Angiogenesis
Oncogenes Symbol Abl Translocation   Indicates Protein Features      
Oncogenes Symbol Cdk-2 Amplification, increased expression   Indicates Protein Features      
Oncogenes Symbol Cdk-4 Point mutation   Indicates Protein Features      
Oncogenes Symbol Cyclin D Amplification, translocation   Indicates Protein Features      
Oncogenes Symbol Cyclin E Amplification   Indicates Protein Features      
Oncogenes Symbol HPV-E7 Viral Infection   Indicates Protein Features      
Tumor Suppressor Symbol p15 Point mutation   Indicates Protein Features      
Tumor Suppressor Symbol p16 Point mutation   Indicates Protein Features      
Tumor Suppressor Symbol p57 Point mutation   Indicates Protein Features      
Tumor Suppressor Symbol Rb Point mutation   Indicates Protein Features      
Table Key:  Oncogenes Tumor Suppressor Symbol Tumor Suppressors Indicates Protein FeaturesIndicates Protein Function

Cell Cycle Control: G2/M DNA Damage Checkpoint

  Protein Genetic
Alterations		 Evading
Apoptosis		 Self-Suffciency
in Growth Status		 Insensitivity to
Anti-Growth Signals		 Tissue Invasion
& Metastasis		 Sustained
Angiogenesis
Oncogenes Symbol Aurora A Amplification, increased expression   Indicates Protein Features      
Oncogenes Symbol HPV-E6 Viral Infection Indicates Protein Features        
Oncogenes Symbol Mdm2 Amplification Indicates Protein Features        
Tumor Suppressor Symbol ARF Point mutation   Indicates Protein Features      
Tumor Suppressor Symbol ATM/ATR Point mutation     Indicates Protein Features    
Tumor Suppressor Symbol BRCA1 Point mutation   Indicates Protein Features Indicates Protein Features    
Tumor Suppressor Symbol Chk1 Point mutation     Indicates Protein Features    
Tumor Suppressor Symbol Chk2 Point mutation     Indicates Protein Features    
Tumor Suppressor Symbol DNA-PK Point mutation     Indicates Protein Features    
Tumor Suppressor Symbol FANCs Point mutation     Indicates Protein Features    
Tumor Suppressor Symbol HIPK2 Point mutation Indicates Protein Features Indicates Protein Features      
Tumor Suppressor Symbol NBS1 Point mutation, deletion     Indicates Protein Features    
Tumor Suppressor Symbol p53 Point mutation, deletion Indicates Protein Features   Indicates Protein Features    
Tumor Suppressor Symbol WT1 Point mutation, deletion          
Tumor Suppressor Symbol MUTYH Point mutation, deletion          
Tumor Suppressor Symbol BLM Point mutation, deletion          
Tumor Suppressor Symbol RECQL4 Point mutation, deletion          
Tumor Suppressor Symbol WRN Deletion, insertion          
Tumor Suppressor Symbol MMR genes Point mutation, reduced expression          
Tumor Suppressor Symbol XPA, C, D Point mutation          
Tumor Suppressor Symbol FBXW7 Point mutation          
Table Key:  Oncogenes Tumor Suppressor Symbol Tumor Suppressors Indicates Protein FeaturesIndicates Protein Function

Death Receptor Signaling Pathway

  Protein Genetic
Alterations		 Evading
Apoptosis		 Self-Suffciency
in Growth Status		 Insensitivity to
Anti-Growth Signals		 Tissue Invasion
& Metastasis		 Sustained
Angiogenesis
Oncogenes Symbol Fas Point mutation Indicates Protein Features        
Table Key:  Oncogenes Tumor Suppressor Symbol Tumor Suppressors Indicates Protein FeaturesIndicates Protein Function

GPCR

  Protein Genetic
Alterations		 Evading
Apoptosis		 Self-Suffciency
in Growth Status		 Insensitivity to
Anti-Growth Signals		 Tissue Invasion
& Metastasis		 Sustained
Angiogenesis
Oncogenes Symbol Ga Point mutation   Indicates Protein Features      
Oncogenes Symbol GPCR Point mutation   Indicates Protein Features      
Table Key:  Oncogenes Tumor Suppressor Symbol Tumor Suppressors Indicates Protein FeaturesIndicates Protein Function

Hedgehog Signaling In Vertebrates

  Protein Genetic
Alterations		 Evading
Apoptosis		 Self-Suffciency
in Growth Status		 Insensitivity to
Anti-Growth Signals		 Tissue Invasion
& Metastasis		 Sustained
Angiogenesis
Oncogenes Symbol Gli Amplification, translocation Indicates Protein Features Indicates Protein Features      
Oncogenes Symbol Hedgehog Point mutation Indicates Protein Features Indicates Protein Features      
Oncogenes Symbol Smo Point mutation Indicates Protein Features Indicates Protein Features      
Tumor Suppressor Symbol Ptch Point mutation Indicates Protein Features Indicates Protein Features      
Tumor Suppressor Symbol Su(Fu) Point mutation Indicates Protein Features Indicates Protein Features      
Tumor Suppressor Symbol EXT1,2 Point mutation, deletion, insertion Indicates Protein Features Indicates Protein Features      
Table Key:  Oncogenes Tumor Suppressor Symbol Tumor Suppressors Indicates Protein FeaturesIndicates Protein Function

Notch Signaling Pathway

  Protein Genetic
Alterations		 Evading
Apoptosis		 Self-Suffciency
in Growth Status		 Insensitivity to
Anti-Growth Signals		 Tissue Invasion
& Metastasis		 Sustained
Angiogenesis
Oncogenes Symbol Notch Translocation Indicates Protein Features        
Table Key:  Oncogenes Tumor Suppressor Symbol Tumor Suppressors Indicates Protein FeaturesIndicates Protein Function

Ras

  Protein Genetic
Alterations		 Evading
Apoptosis		 Self-Suffciency
in Growth Status		 Insensitivity to
Anti-Growth Signals		 Tissue Invasion
& Metastasis		 Sustained
Angiogenesis
Oncogenes Symbol B-Raf Point mutation, amplification, increased expression   Indicates Protein Features      
Oncogenes Symbol Fos/Jun Increased expression Indicates Protein Features Indicates Protein Features      
Oncogenes Symbol ILK Increased expression   Indicates Protein Features   Indicates Protein Features  
Oncogenes Symbol Ras Point mutation   Indicates Protein Features      
Oncogenes Symbol RTKs Point mutation, translocation, amplification, increased expression Indicates Protein Features Indicates Protein Features   Indicates Protein Features Indicates Protein Features
Tumor Suppressor Symbol Integrin Deletion       Indicates Protein Features  
Tumor Suppressor Symbol NF1 Point mutation, deletion   Indicates Protein Features      
Tumor Suppressor Symbol NF2 Point mutation, deletion   Indicates Protein Features   Indicates Protein Features  
Tumor Suppressor Symbol VHL Point mutation         Indicates Protein Features
Tumor Suppressor Symbol FH Point mutation          
Tumor Suppressor Symbol SDH Point mutation, deletion          
Table Key:  Oncogenes Tumor Suppressor Symbol Tumor Suppressors Indicates Protein FeaturesIndicates Protein Function

TGF-β Signaling Pathway

  Protein Genetic
Alterations		 Evading
Apoptosis		 Self-Suffciency
in Growth Status		 Insensitivity to
Anti-Growth Signals		 Tissue Invasion
& Metastasis		 Sustained
Angiogenesis
Oncogenes Symbol Myc Point mutation, amplification   Indicates Protein Features      
Tumor Suppressor Symbol BMPR Point mutation     Indicates Protein Features    
Tumor Suppressor Symbol Smad2/3 Point mutation     Indicates Protein Features    
Tumor Suppressor Symbol Smad4 Point mutation     Indicates Protein Features    
Tumor Suppressor Symbol TGFβR Point mutation     Indicates Protein Features    
Tumor Suppressor Symbol MEN1 Point mutation     Indicates Protein Features    
Table Key:  Oncogenes Tumor Suppressor Symbol Tumor Suppressors Indicates Protein FeaturesIndicates Protein Function

Wnt/β-Catenin Signaling

  Protein Genetic
Alterations		 Evading
Apoptosis		 Self-Suffciency
in Growth Status		 Insensitivity to
Anti-Growth Signals		 Tissue Invasion
& Metastasis		 Sustained
Angiogenesis
Oncogenes Symbol β-catenin Point mutation   Indicates Protein Features      
Oncogenes Symbol RAR Amplification   Indicates Protein Features      
Oncogenes Symbol SOX Amplification, increased expression   Indicates Protein Features      
Oncogenes Symbol Wnt1 Increased expression   Indicates Protein Features      
Tumor Suppressor Symbol APC Point mutation   Indicates Protein Features      
Tumor Suppressor Symbol Axin Point mutation   Indicates Protein Features      
Tumor Suppressor Symbol α-catenin Point mutation       Indicates Protein Features  
Tumor Suppressor Symbol E-cadherin Point mutation   Indicates Protein Features Indicates Protein Features Indicates Protein Features  
Tumor Suppressor Symbol Wnt5A Point mutation   Indicates Protein Features      
Tumor Suppressor Symbol GPC3 Deletions, point mutation   Indicates Protein Features      
Tumor Suppressor Symbol HRPT2 Point mutation   Indicates Protein Features      
Table Key:  Oncogenes Tumor Suppressor Symbol Tumor Suppressors Indicates Protein FeaturesIndicates Protein Function

Other / TFs

  Protein Genetic
Alterations		 Evading
Apoptosis		 Self-Suffciency
in Growth Status		 Insensitivity to
Anti-Growth Signals		 Tissue Invasion
& Metastasis		 Sustained
Angiogenesis
Oncogenes Symbol TAL1 Translocation   Indicates Protein Features      
Oncogenes Symbol MLL Translocation   Indicates Protein Features      
Oncogenes Symbol HOXs Translocation, point mutation   Indicates Protein Features      
Oncogenes Symbol MITF Amplification Indicates Protein Features Indicates Protein Features      
Oncogenes Symbol EVI1 Translocation Indicates Protein Features        
Oncogenes Symbol BCL6 Translocation, point mutation          
Tumor Suppressor Symbol HPC1 Point mutation          
Table Key:  Oncogenes Tumor Suppressor Symbol Tumor Suppressors Indicates Protein FeaturesIndicates Protein Function