Jak/Stat Utilization Table

Combinatorial use of Tyrosine Kinases and Stat Proteins in Cytokine/Growth Factor Signaling.

Ligand	Receptor	Jak-kinase	Other Tyrosine Kinases	Stat Family Members
IL-6	IL-6Ra+gp130	Jak1, Jak2, Tyk2	Hck	Stat1, Stat3
IL-11	IL-11R+gp130	Jak1, Jak2, Tyk2	Src, Yes	Stat3
CNTF, CT-1, LIF, OSM	CNTFR+gp130, CT-1R+gp130, LIFR+gp130, OSMR+gp130	Jak1, Jak2, Tyk2	Src family	Predominant: Stat3 Secondary: Stat1, Stat5
G-CSF	G-CSFR	Jak2, Tyk2	Lyn	Stat3
IL-12	IL-12Rβ1+IL-12Rβ2	Jak2, Tyk2	Lck	Stat4
Leptin	LeptinR	Jak2	not determined	Stat3, Stat5, Stat6
IL-3	IL-3Rα+βc	Jak2	Fyn, Hck, Lyn	Stat3, Stat5, Stat6
IL-5	IL5R+βc	Jak2	Btk	Stat3, Stat5, Stat6
GM-CSF	GM-CSFR+βc	Jak2	Hck, Lyn	Stat3, Stat5
Angiotensin	GPCR	Jak2, Tyk2		Stat1, Stat2, Stat3
Serotonin	GPCR	Jak2		Stat3
α-Thrombin	GPCR	Jak2		Stat1, Stat3
Chemokines	CXCR4	Jak2, Jak3
IL-2	IL-2Rα+IL-2Rb+γc	Jak1, Jak2, Jak3	Fyn, Hck, Lck, Syk, Tec	Stat3, Stat5
IL-4	IL-4+γcR	Jak1, Jak3	Lck, Tec	Stat6
IL-7	IL-7R+γc	Jak1, Jak3	Lyn	Stat3, Stat5
IL-9	IL-9R+γc	Jak1, Jak3	not determined	Stat1, Stat3, Stat5
IL-13	IL-13R+γc	Jak1, Jak2, Tyk2	Ctk	Stat6
IL-15	IL-15Rα+IL-2Rβ+γc	Jak1, Jak3	Lck	Stat3, Stat5
IL-19	IL-20Rα+IL-20Rβ	Jak1, ?		Stat3
IL-20	IL-20Rα, IL-22R+IL-20Rβ	Jak1, ?		Stat3
IL-21	IL-21R+γc			Stat1, Stat3, Stat5
IL-22	IL-22R+IL-10Rβ	Jak1, Tyk2		Stat1, Stat3, Stat5
IL-23	IL-12Rβ1+IL-23R	Jak2	Tyk2	Stat4
IL-24	same as IL-20	Jak1, ?		Stat3
IL-26	IL-20Rα+IL-10Rβ	Jak1, Tyk2		Stat3
IL-27	IL-27R	Jak1, Jak2, Tyk2		Stat1, Stat2, Stat3, Stat4, Stat5
IL-28A, IL28B, IL29	IL-28R+IL-10Rβ	Jak1, Tyk2		Stat1, Stat2, Stat3, Stat4, Stat5
GH	GHR	Jak2	Src family	Stat3, Stat5 (mainly Stat5a)
Tpo	TpoR (c-Mpl)	Tyk2, Jak2	Lyn	Stat1, Stat3, Stat5
Epo, Pro	EpoR, ProlactinR	Jak2	Src Family	Stat5 (mainly Stat5a)
Interferon (IFNα/β)	IFNAR1+IFNAR2	Jak1, Tyk2	Lck	Predominant: Stat1, Stat2 Secondary: Stat3, Stat4, Stat5
IFN-γ	IFN-gR1+IFN-γR2	Jak1, Jak2	Hck, Lyn	Stat1
IL-10	IL-10Rα+ IL-10Rβ	Jak1, Tyk2	not determined	Stat3, Stat1, Stat5
EGF	EGFR	Jak1	EGFR, Src	Stat1, Stat3, Stat5
PDGF	PDGFR	Jak1, Jak2	PDGFR, Src	Stat1, Stat3, Stat5

CST would like to thank Prof. Stefan N. Constantinescu, Ludwig Institute for Cancer Research, Brussels, Belgium, for contributing to this table.