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Research Associate - Chromatin IP (ChIP)

Danvers, MA

Cell Signaling Technology, Inc. (CST) is a worldwide leader in the development and commercialization of antibodies, assays and research tools. As a company of scientists for scientists, we have developed PTMScan®, a technology to discover protein post-translational modifications, PhosphoSitePlus®, an online resource for investigation of post-translational modifications, and XMT® technology, a proprietary method to develop exceptional monoclonal antibodies. We are fully committed to developing new research tools to help define the mechanisms underlying cell function and disease, thereby broadly accelerating progress in biomedical research and medicine.

We are currently seeking a highly motivated Research Associate to join a team dedicated to the development of epigenetics-based assays. The candidate will contribute to the development of innovative research tools, with a primary focus on antibody validation and assay development for chromatin IP (ChIP) and ChIP-Seq. Major lab techniques include cell lysate preparation, ChIP, DNA purification, PCR, DNA sequencing library preparation and cell culture. Applicants must be able to design moderately complex experiments with proper controls and are expected to independently interpret and report results.


  • Collaborate with senior project scientists and other research associates to manage a fast-paced pipeline and complete scientific tasks on aggressive timelines to support internal and external customers
  • Independently test antibody and reagent performance in chromatin IP (ChIP) assays. Techniques include cell culture, cell lysate preparation, chromatin IP, DNA purification, qPCR, and DNA sequencing library preparation
  • Independently analyze experimental data and communicate results to senior project scientists via presentation and email
  • Identify, analyze and troubleshoot technical issues relating to antibody and reagent performance in the ChIP assay
  • Collaborate with senior project scientists to identify, develop, and release new protocols and products to support ChIP workflow
  • Provide support to colleagues in the commercial organization by reviewing datasheets and technical literature, generating scientific content for webinars and other marketing collateral, and hosting technical training sessions for internal customers
  • May also involve travel to scientific conferences to provide ChIP support for external customers at the company booth
  • Engage directly with internal and external customers to provide technical assistance via email and phone. Troubleshoot unexpected ChIP results and assist with experimental design questions.


  • BA/BS, or MS degree in a biological science (e.g. Molecular Biology, Cell Biology, Biochemistry or Biotechnology)
  • 2+ years of post-graduate laboratory experience
  • Hands-on experience with cell culture, PCR and immunoprecipitation

Preferred Skills:

  • Experience with ChIP assay
  • Strong organizational skills and attention to detail
  • Ability to work independently with a collaborative mindset
  • Ability to multi-task effectively and manage multiple priorities at one time
  • Strong verbal and written communication skills and ability to thrive in a team environment
  • Familiarity with computer programs such as Microsoft Word, Excel and PowerPoint


You will be taken to an external website, please attach your cover letter and resume as one document and refer to job code RAEPI-2016-R when applying.