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Director, Computational Biology and Bioinformatics

Danvers, MA

Cell Signaling Technology, Inc. (CST) is a worldwide leader in the development and commercialization of antibodies, assays and research tools. As a company of scientists for scientists, we have developed PTMScan®, a technology to discover protein post-translational modifications, PhosphoSitePlus®, an online resource for investigation of post-translational modifications, and XMT® technology, a proprietary method to develop exceptional monoclonal antibodies. We are fully committed to developing new research tools to help define the mechanisms underlying cell function and disease, thereby broadly accelerating progress in biomedical research and medicine.

The Director will be responsible for the strategic vision, planning and execution of all bioinformatics activities and programs at CST. The Director will lead a bioinformatics and computational biology group with both internally- and externally-facing facets. Among other responsibilities, the Director would help provide strategic leadership of CST's PhosphoSitePlus database of protein sequences and post-translational modifications, and lead efforts involving NGS and proteomics data processing and analysis, leveraging both public and private datasets to meet the needs of all -omics customers, both internal and external. The successful candidate will be service-focused and will collaborate enthusiastically with multiple departments across the organization.


  • Act as subject matter expert on bioinformatics algorithms, statistical analysis, proteomic and genomic data analysis
  • Lead a team that supports & develops genomic and proteomic data analysis pipelines
  • Collaborate cross-functionally to ensure adequate service to research and development groups and integration of systems with broader IT network at CST
  • Direct the development of new tools for integrative analysis of NGS and proteomics data
  • Explore and implement, as appropriate, new tools for analysis of proteomic data sets
  • Ensure quality control, and maintain accurate software versioning, etc.
  • Identify, procure, and analyze external data sets that help to drive the mission of CST
  • Set strategic direction in the use of application frameworks in support of bioinformatic workflows
  • Oversee migration to scalable application infrastructure leveraging Amazon AWS


  • PhD in Bioinformatics, Computational Biology, Biostatistics, Physics, or equivalent experience
  • 10+ years relevant experience, with 5 years in an industry setting
  • Minimum of 5 years experience managing other bioinformatics scientists
  • Significant experience in analysis of large proteomics data sets with track record of publication and/or software development
  • Experience with analysis of large genomics data sets and integration with proteomics data; RNA-seq, ChIP-seq
  • Demonstrated fluency in Software Engineering, Application Architecture, open-source frameworks, Python, Matlab, Java
  • Must have strong computational protein/post-translational modification bioinformatics background

Preferred Skills/Experience:

  • Deep understanding of biostatistics as relates to large dataset analysis
  • Experience with de novo peptide sequencing by mass spectrometry
  • Excellent understanding of proteomics, genomics, and related analysis tools
  • Demonstrated ability to balance competing priorities
  • Excellent oral and written communication skills


You will be taken to an external website, please attach your cover letter and resume as one document and refer to job code DIRBIOINF-2016-N when applying.