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The Ras Mouse mAb #8832 included in the Active Ras Detection Kit #8821 will detect H, K, and N Ras. It cross-reacts with human, mouse, and rat Ras.
Our Ras (G12D Mutant Specific) (D8H7) Rabbit mAb #14429 and Ras (G12V Mutant Specific) (D2H12) Rabbit mAb #14412 will detect all three types of Ras (H-Ras, K-Ras, and N-Ras) if the respective mutations are present.
Melanomas account for 90% of skin cancer deaths. A big contributor to this: the lack of effective, durable treatments for unresectable, metastatic melanoma.
A scientific resource for the IQ protein domain containing information on structure, function, and domain binding to calmodulin.
A scientific resource for the PB1 protein domain containing information on structure, function, and domain binding in cytoskeletal signaling proteins.
The antigen for our Rab5A Antibody #2143 corresponds to residues surrounding Gly190 of human Ras-related protein Rab-5A (UniProt ID P20339). The antibody is predicted to cross-react with endogenous levels of Ras-related protein Rab-5A, but is not expected to cross-react with Ras-related proteins Rab-5B or Rab-5C.
Expert-reviewed interactive pathway providing a current overview of Glutamine Metabolism signaling pathway.
A number of growth factors and cytokines can induce an Epithelial-Mesenchymal Transition (EMT) in tumor cells.
Explore the ERK pathway and its role in cell proliferation and survival. Click here to read more about this critical signaling pathway.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
There's a need for new methods to diagnose and treat pancreatic cancer. Biomarkers like CA 19-9 and MUC5AC are being explored as prognosis indicators.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
Discover the insulin signaling pathway and its role in glucose metabolism & diabetes. Learn more about insulin action here.
Each GTPase Assay Kit provides enough reagents for 30 immunoprecipitations based on the amount of GST-fusion protein, Spin Cups, and Collection Tubes provided. The GTP and GDP is only enough for 10 assays. These two reagents are intended to be used as positive and negative controls alongside your own samples. For example, if working with a cell line treated with a compound to see if it would induce active Ras signaling (when using our Active Ras Detection Kit #8821, specifically), one would want to run these samples with GTP + GST-Raf1-RBD (positive control), GDP + GST-Raf1-RBD (negative control), and the samples + GST-Raf1-RBD to see if the treatment effectively induced active Ras compared to the positive control. In other words, GTP and GDP are usually not added to all 30 assays; 10 assays worth is typically an appropriate amount of these controls.
Summary of human oncogenes and tumor suppressor genes sorted by signaling pathway.
Explore the G protein coupled receptor signaling pathway and its diverse roles in cellular communication. Read more here.
Expert-reviewed diagram providing a current overview of the m6A RNA pathway with references to its role in tumor development
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
PhosphoScan® Phosphorylation Proteomics
UbiScan® - Ubiquitination Proteomics
AcylScan™ - Acylation Proteomics
Expert-reviewed interactive pathway providing a current overview of the Warburg Effect.
Scientists used around 30 different Cell Signaling Technology® antibodies to characterize the Ras GTPase-activating protein-binding proteins G3BP1 and G3BP2.
PTMScan Motif Antibodies and Kits, for customers who purchase a license and would like to perform PTMScan Proteomics in-house.
PTMScan Motif Antibody Kits from Cell Signaling Technology
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
KinomeView® Profiling Kit and Services
