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14-3-3 Protein Domain (Protein Domains)

A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.

2021 Grants Program

Grant application guidelines and project description criteria for funding from CST in 2021.

About CST Tech Support (Process Explanations)

If you contact CST for technical support, the same scientists who produced and validated your antibody will personally answer your telephone call or email, sharing their experience and their data.

About Our Reviews

Honest description of how reviews are handled for CST products.

About Us

Summary description of CST with the mission statement and corporate commitment.

ADF Protein Domain (Protein Domains)

A scientific resource for the ADF protein domain containing information on structure, function, and binding to monomeric and filamentous actin.

Adhesion/ECM/Cytoskeleton (Pathway Diagram)

Overview of Adhesion and Extracellular Matrix signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources.

AGC Protein Kinase Group (Kinome Diagram)

A kinome diagram showing the ACG group of protein kinases.

Akt Antibody Comparison Tables

Compare Cell Signaling Technology's Akt antibodies against one another to determine optimal applications

Akt Signaling (Product Type Overviews)

Phospho-Akt product and resources including product citations, educational videos and pathways, product selection tools and comparison data from Cell Signaling Technology.

ALK and ROS1 - Disease Drivers in Cancer

Identification of ALK and ROS1 fusion proteins in non-small cell lung cancer (NSCLC) at Cell Signaling Technology (CST).

Alternative Transportation Plan

CST promotes alternative transportation through a variety of programs.

Amyloid Beta: Amyloid Precursor Protein (APP)

Amyloid beta is a protein fragment of the amyloid precursor protein, and is the major component of Alzheimer’s disease plaques.

An Introduction to Epigenetics

3D video animation of histone modifications and their effects on chromatin activation

Analysis of Immunohistochemistry (IHC) Staining

Learn how to best interpret IHC staining and understand experiment results accurately.

Angiogenesis Resources (Pathway Diagram)

Overview of Angiogenesis antibodies & related reagents, interactive pathway diagrams, and other technical resources.

ANK Protein Domain (Protein Domains)

A scientific resource for the ANK protein domain containing information on structure, function, and binding partners.

Antibody Request Sent

Customer thank you for new product suggestion. Link to “Fresh off the Bench” newsletter subscription.

Antibody Validation for Flow Cytometry (Process Explanations)

Validation for flow cytometry antibodies from CST Cell Signaling Technology

Antibody Validation for Immunofluorescence (Process Explanations)

Validation for IF antibodies at CST Cell Signaling Technology

Antibody Validation for Immunohistochemistry (Process Explanations)

An outline and examples of the steps performed at Cell Signaling Technology to validate target specificity of an antibody for use in immunohistochemical analysis.

Antibody Validation for Western Blotting (Process Explanations)

The accuracy of western blot results relies heavily of the quality of the primary antibody used. CST™ antibodies are validated using multiple experiments.

Antibody-Based Techniques to Study Neurodegenerative Diseases

A broad range of techniques are used to study neurodegenerative diseases including basic cellular and molecular protocols, ELISA, electrophysiological assessments, and imaging-based methods that utilize antibody-based technology.

Apoptosome Formation and Activation

This Apoptosome video is a 3D animation illustrating key steps in Caspase-mediated formation and activation of the apoptosome, leading to cell death.

Application Solutions Kits (Application Overviews)

CST now offers cost-effective, efficient, and convenient reagent kits to help facilitate western blot, immunofluorescent, and immunohistochemistry experiments.

Applications (Application Overviews)

CST antibodies are extensively validated in-house for Western Blotting, Flow Cytometry, Immunohistochemistry, Immunofluorescence and Chromatin Immunoprecipitation by dedicated scientists.

ARM Protein Domain (Protein Domains)

A scientific resource for the ARM protein domain containing information on structure, function, and domain binding.

Assay Protocol for Glucose-6-Phosphate Dehydrogenase (G6PD) Activity Assay Kit #12581 (Protocols)

6-Phosphate Dehydrogenase (G6PD) Activity Assay Kit #12581; easy to follow directions describing the step by step experimental procedure.

Atypical Protein Kinases (Kinome Diagram)

Kinome diagrams showing the atypical protein kinase groups.

Autophagy Research Resources (Pathway Diagram)

Overview of autophagy signaling, antibodies and related reagents, interactive pathway diagrams, and technical resources for autophagy research.

B7-H3 & B7-H4

Highly specific and sensitive rabbit mAbs against B7 family targets, B7-H3 & B7-H4, are proven to outperform existing clones by WB.

BAR Protein Domain (Protein Domains)

A scientific resource for the BAR protein domain containing information on structure, function, and binding to phospholipids.

BCL6 Rabbit Monoclonal Antibody (Product Type Overviews)

Western blot data shows strength and specificity of CST BCL6 (D4I2V) XP® Rabbit mAb #14895 compared to another company's mouse mAb. CST antibody is validated for WB, IP, IF, Flow, and ChIP.

BEACH Protein Domain (Protein Domains)

A scientific resource for the BEACH protein domain containing information on structure, function, and phospholipid binding.

Benefits of Enzyme-based Chromatin Digestion (Application Overviews)

The benefits of using micrococcal nuclease to digest chromatin compared to sonication.

BH1-4 Protein Domains (Protein Domains)

A scientific resource for the BH protein domains containing information on structure, function, and domain binding in apoptosis.

BIR Protein Domain (Protein Domains)

A scientific resource for the BIR protein domain containing information on structure, function, and domain binding in apoptosis.

Blocking Peptide Custom Pricing Request

Custom pricing request form for blocking peptides.

BRCT Protein Domain (Protein Domains)

A scientific resource for the BRCT protein domain containing information on structure, function, and binding to phospho-serine motifs.

BrdU Cell Proliferation Chemiluminescent Protocol (Protocols)

BrdU Cell Proliferation Chemiluminescent Protocol: easy to follow directions describing the step by step experimental procedure.

BrdU Cell Proliferation Protocol (Protocols)

BrdU Cell Proliferation Protocol: easy to follow directions describing the step by step experimental procedure.

BROMO Protein Domain (Protein Domains)

A scientific resource for the BROMO protein domain containing information on structure, function, and binding to aceylated-lysine residues during chromatin remodeling.

BTB/POZ Protein Domain (Protein Domains)

A scientific resource for the BTB/POZ protein domain containing information on structure, function, and domain binding during chromatin remodeling.

C1 Protein Domain (Protein Domains)

A scientific resource for the C1 protein domain containing information on structure, function, and binding to phospholipids.

C2 Protein Domain (Protein Domains)

A scientific resource for the C2 protein domain containing information on structure, function, and binding to phospholipids.

CALM Protein Domain (Protein Domains)

A scientific resource for the CALM protein domain, also known as ANTH domain, containing information on structure, function, and binding to phospholipids.

CAMK Protein Kinases (Kinome Diagram)

A kinome diagram showing the CAMK group of protein kinases.

Cancer Publications from CST

List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).

CAR Signaling Networks Interactive Pathway (Pathway Diagram)

Interact with this CAR-T signaling pathway to learn how the combination of extracellular and intracellular domains, including CD8, CD28, 4-1BB, OX40, or CD27, exert antitumor effects.

CARD Protein Domain (Protein Domains)

A scientific resource for the CARD protein domain containing information on structure, function, and domain binding during apoptosis.

Carrier-free Antibodies for Mass Cytometry

CST offers flow validated antibodies for single cell mass cytometry (MC) and IHC validated antibodies for imaging mass cytometry (IMC)

Caspase-3 Activity Protocol (Protocols)

Caspase-3 Activity Protocol: easy to follow directions describing the step by step experimental procedure.

Caspase-3 Antibody Comparison Table

Compare Cell Signaling Technology's Cleaved Caspase antibodies against one another to determine optimal applications.

Caspase-3 Signaling (Product Type Overviews)

Cleaved caspase-3 product listings, product citation lists,product selection tools, comparison tables and educational resources for apoptosis signaling from Cell Signaling Technology.

CC Protein Domain (Protein Domains)

A scientific resource for the coiled coil (CC) protein domain containing information on structure, function, and domain binding.

CD Markers (Pathway Diagram)

A list of important CD markers that includes links to PhosphoSitePlus, Uniprot, and products from Cell Signaling Technology.

Cell Cycle Regulation (Pathway Diagram)

Overview of cell cycle and DNA damage signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources.

Cell Death (Pathway Diagram)

Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.

Cellular Landscapes (Cellular Landscapes)

A listing of interactive 3D molecular models displaying signal transduction pathways in the context of their cellular landscapes produced by Cell Signaling Technology.

Cellular Landscapes: Adhesion (Cellular Landscapes)

Interactive 3D molecular model depicting key adhesion signaling pathway nodes within their cellular landscape and integrated with PhosphoSitePlus protein pages.

Cellular Landscapes: Mitochondria

Interactive 3D molecular model depicting the cellular landscape of mitochondria and it's various protein subsets including Apoptosis, Cytoskeleton, Warburg, etc.

Cellular Landscapes: Nucleus

An interactive 3D molecular model depicting the cellular landscape of a nucleus and it's various protein subsets including DNA Damage, Replication, Transcription, etc.

Cellular Landscapes: Protein Synthesis (Cellular Landscapes)

Interactive 3D molecular model depicting key adhesion signaling pathway nodes within their cellular landscape and integrated with PhosphoSitePlus protein pages.

Cellular Landscapes: Receptor Tyrosine Kinase (RTK) (Cellular Landscapes)

Interactive 3D molecular model depicting key RTK signaling pathways including c-Kit, EGFR, etc, and integrated with PhosphoSitePlus® protein pages.

Cellular Landscapes: Vesicle Trafficking (Cellular Landscapes)

Interactive 3D molecular model depicting key Vesicle Trafficking nodes within their cellular landscape and integrated with PhosphoSitePlus protein pages.

Cellular Metabolism (Pathway Diagram)

Overview of Cellular Metabolism pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources

Cellular Senescence

Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.

Certifications

Cell Signaling Technology, Inc. (CST) is ISO 9001:2008 certified for the design, development, and production of monoclonal antibodies (mAbs).

CH Protein Domain (Protein Domains)

A scientific resource for the CH protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.

Changes to Recommended Western Blotting Protocols (Protocols)

A demonstration of the perils of deviating from Cell Signaling Technology's recommended protocols.

ChIP Validated Antibodies and Primer Pairs (Application Overviews)

SimpleChIP® Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.

ChIP-seq Ab Performance Comparison (Product Type Overviews)

ChIP-seq is a powerful technique that combines ChIP and next-generation sequencing (NGS) to study DNA-protein interactions across the entire genome, but it is only as good as the quality of the antibody used in the ChIP experiment.

ChIP-seq Validated Antibodies

ChIP-seq is a powerful technique that combines ChIP and next-generation sequencing (NGS) to study DNA-protein interactions across the entire genome, but it is only as good as the quality of the antibody used in the ChIP experiment.

ChIP-Sequencing performed using the SimpleChIP® Kit (Application Overviews)

Use SimpleChIP kits to perform high throughput ChIP-Sequencing and assay genome wide changes in histone modifications and transcription factor binding.

Chromatin Immunoprecipitation (ChIP) Resource Center (Application Overviews)

Comprehensive SimpleChIP® kits and ChIP validated antibodies from CST and validated ChIP reagents (primer pairs, Protein G agarose and magnetic beads

Chromatin Immunoprecipitation Technical Support (Application Overviews)

Detailed technical support information to support ChIP experimental success. LInk to CST's comprehensive ChIP protocol.

Chromatin Immunoprecipitation Troubleshooting Guide (Protocols)

Chromatin Immunoprecipitation Troubleshooting Guide: easy to follow directions describing the step by step experimental procedure.

Chromatin Immunoprecipitation Workflow Solutions for ChIP-qPCR and ChIP-seq (Application Overviews)

Chromatin Immunoprecipitation Workflow Solutions for ChIP-qPCR and ChIP-seq

Chromatin IP Frequently Asked Questions (Application Overviews)

Chromatin IP (ChIP) Frequently Asked Questions (FAQs) from Cell Signaling Technology, Inc.

Chromo Protein Domain (Protein Domains)

A scientific resource for the Chromo protein domain containing information on structure, function, and binding to methylated lysine residues during chromatin remodeling.

CK1 Protein Kinases Group (Kinome Diagram)

A kinome diagram showing the CK1 family of protein kinases.

CMGC Protein Kinases Group (Kinome Diagram)

A kinome diagram showing the CMGC group of protein kinases.

Commitment to Science

Summary description of CST with the mission statement and corporate commitment.

Commitment to the Arts

CST continues to be a strong patron of the arts with in-house galleries highlighting the work of local and regional artists.

Common Pluripotency Markers

Highlighted common pluripotency markers with a brief description of their expression from Cell Signaling Technology

Community Gardens

CST has a backyard garden program for employees to participate in.

Community Grants

Grant application guidelines and project description criteria for funding from CST.

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