Basket Updated
0
Items added
Mutations in cell death pathways, such as apoptosis, mitophagy, necroptosis, and autophagy, contribute to neuronal cell death and the progression of neurodegenerative diseases.
The key to identifying neurons, microglia, oligodendrocytes, and astrocytes lies in using antibodies that target protein biomarkers specifically expressed and localized within these cells.
There are a number of markers that can be used to distinguish the many cell types of the central and peripheral nervous system during development, adult neurogenesis, and the pathogenesis of neurodegenerative disorders.
Validation for IF antibodies at CST Cell Signaling Technology
We’ve put together a starter’s guide on the cellular mechanisms that drive neurodegeneration in diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease.
Epigenetic regulation, including aberrant DNA methylation and histone modifications, have been linked to Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis.
Neuroinflammation is a condition observed in the central nervous system (CNS) in response to infection, toxic metabolites, traumatic injury, or autoimmunity.
Abnormal cell-cell communication, for example disrupted presynaptic input, as well as disrupted intracellular signaling contribute to the pathogenesis of neurodegenerative disease.
Apoptosis is a type of programmed cell death that occurs normally throughout the lifespan and can also occur in response to harmful stimuli. Apoptotic cells are identified by their altered morphology, caspase activation, and the presence of damaged DNA.
Cellular senescence is characterized by irreversible cell-cycle arrest in combination with a distinct secretory phenotype and expanded lysosomes in response to stress. Senescent cells accumulate in tissues during aging, and various markers of senescence
Modulation of CNS function occurs through synaptic neurotransmission, which is the signaling from the axon terminal of one neuron to the dendrites of another via molecules called neurotransmitters.
The three main purposes of metabolism are the conversion of food to energy; the conversion of nutrients to proteins, carbohydrates, lipids, and nucleic acids; and the elimination of nitrogenous wastes. There is a strong correlation between metabolic chan
Co-staining with multiple antibodies is a low-content form of multiplex analysis that be achieved using different host species or fluorophore conjugates.
Discover the epigenetic drivers that help drive MDS / AML cancers
Neuroinflammation is the activation of an immune response in the CNS by the microglia and astrocytes. While not linked mechanistically to neurodegenerative diseases, neuroinflammation is associated with the progression of Alzheimer’s disease, Parkinson’s
Case Study 4: Exceptional Performance of XP Monoclonal Antibodies from Cell Signaling Technology.
Neurodegeneration refers to disorders of the CNS that lead to loss of neurons or glia, and is associated with age-related diseases, autoimmune attacks on the nervous system, or genetic mutations that affect the heath of CNS cells.
Metabolism defines all of the chemical changes or processes within cells, tissues, and organisms that sustain cellular homeostasis.
Cell viability assays measure the population of live, viable cells within a sample. Typically, viability assays measure markers of cell health, including cellular metabolism, ATP levels, and cell proliferation.
Streamline your neurodegeneration therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
Tau is a microtubule-associated protein found in neurons, and its function is to stabilize axonal microtubules. Hyperphosphorylated tau is a hallmark of several neurodegenerative diseases including Alzheimer’s disease.
Chronic neuroinflammation is associated with neurodegenerative diseases like Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and others.
The immune system is composed of tissues, cells, and molecules whose primary function is to detect, respond to, and eliminate pathogens and transformed cells.
Flow Cytometry BrdU Modified Protocol: easy to follow directions describing the step by step experimental procedure.
Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.
Cleaved caspase-3 product listings, product citations, comparison tables and educational resources for apoptosis signaling from Cell Signaling Technology.
A broad range of techniques are used to study neurodegenerative diseases including basic cellular and molecular protocols, ELISA, electrophysiological assessments, and imaging-based methods that utilize antibody-based technology.
Beyond our recommended immunofluorescence protocols, here are additional considerations when planning your IF imaging experiment.