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Neural and Glial Cell Markers

There are a number of markers that can be used to distinguish the many cell types of the central and peripheral nervous system during development, adult neurogenesis, and the pathogenesis of neurodegenerative disorders.

Overview of Metabolism and Metabolic Disorders

Metabolism defines all of the chemical changes or processes within cells, tissues, and organisms that sustain cellular homeostasis.

Neurotransmitters, Receptors, and Transporters

Modulation of CNS function occurs through synaptic neurotransmission, which is the signaling from the axon terminal of one neuron to the dendrites of another via molecules called neurotransmitters.

Neuroinflammation in Neurodegenerative Diseases

Neuroinflammation is the activation of an immune response in the CNS by the microglia and astrocytes. While not linked mechanistically to neurodegenerative diseases, neuroinflammation is associated with the progression of Alzheimer's disease, Parkinson's

Understanding Neurodegenerative (NDG) Diseases

Neurodegeneration refers to disorders of the CNS that lead to loss of neurons or glia, and is associated with age-related diseases, autoimmune attacks on the nervous system, or genetic mutations that affect the heath of CNS cells.

Synopsis of Cell Proliferation, Metabolic Status, and Cell Death

Cell viability is a measure of the proportion of live, healthy cells within a population. Assays to assess cell viability measure metabolic activity, ATP content, cell proliferation, or membrane integrity.

Tau Protein and Neurofibrillary Tangles

Tau is a microtubule-associated protein found in neurons, and its function is to stabilize axonal microtubules. Hyperphosphorylated tau is a hallmark of several neurodegenerative diseases including Alzheimer’s disease.

Flow Cytometry Troubleshooting Guide (Protocols)

Troubleshooting tips for successfully performing Intracellular Flow Cytometry using CST recommended protocols and antibodies validated for Flow.

Understanding the Role of RNA Regulation and Epitranscriptomics in Disease

RNA Regulation, Epitranscriptomics, and Disease | Cell Signaling Technology

Flow Cytometry BrdU Modified Protocol (Protocols)

Flow Cytometry BrdU Modified Protocol: easy to follow directions describing the step by step experimental procedure.

Antibody-Based Techniques to Study Neurodegenerative Diseases

A broad range of techniques are used to study neurodegenerative diseases including basic cellular and molecular protocols, ELISA, electrophysiological assessments, and imaging-based methods that utilize antibody-based technology.

Exceptional Performance of XP® Monoclonal Antibodies (Product Type Overviews)

Case Study 4: Exceptional Performance of XP Monoclonal Antibodies in All Applications pertaining to eXceptional Monoclonal Technology (XMT) from Cell Signaling Technology.

What Is Immunohistochemistry (IHC) Staining?

Discover how to successfully stain tissue with antibodies for immunohistochemistry (IHC) experiments. See examples of successfully stained IHC assays.

Understand Protein Expression in Tissue with Immunohistochemistry (IHC) (Application Overviews)

Learn how to visualize protein expression in tissue with immunohistochemistry (IHC). See examples of successfully optimized IHC assays.

In-Cell Western™ (Application Overviews)

In-cell Western: a simple method for quantification of intracellular signaling in whole cells. Data and links for tech support.

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