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Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.
Regulation of cell death due to viral infection is important for host survival. In this series, we look at pathways regulated through cellular responses to viruses.
In an effort to curb carbon emissions, highway congestion and promote employee wellbeing, CST drafted an Alternative Transportation Plan (ATP).
Bay State Bike Week and the Mass Commute Bicycle Challenge is a great event to promote cycling and build community spirit. CST is looking forward to Bike Week next year where we hope to break the 2,100 mile mark!
Networking is an important part of any research career but can cause anxiety for many. These tips will help you prepare and make the process more enjoyable
CST promotes alternative transportation through a variety of programs.
Explore the mitochondrial apoptosis pathway and its role in programmed cell death. Read more about this essential pathway here.
CST is a proud member of the 1% for the Planet organization, giving annually to benefit social and environmental causes.
Each summer, college and high school interns at CST get a chance to sample work life in a biotech environment. Students at this stage are typically considering potential career paths, so what better time to set up a Q&A panel? Five CST employees shared some of their career development experiences.
Either sonication or enzymatic digestion may be used to fragment chromatin for ChIP, but first consider your sample type, protein target, and downstream analysis.
How much antibody should I use for chromatin immunoprecipitation? Watch this Tech Tips video to learn why more antibody isn't always better.
It’s the start of another exciting year of Lab Expectation articles. What can you expect from us in 2021?
How does the choice of blocking protein—nonfat dry milk vs bovine serum albumen (BSA)—affect your western blot (WB) results? Watch the Tech Tips video.
Season's Greetings from CST!
Study the intricate machinery of the apoptosis signaling pathway. Click here to learn more and gain insights into programmed cell death mechanisms.
Will an antibody validated for WB perform as expected in an IF experiment? Here, we compare an IF-validated mAb from CST to one from another vendor.
Cell Signaling Technology (CST) talks March for Science and what we can do to stay green this upcoming Earth Day.
Do polyclonal have an advantage over monoclonals for chromatin immunoprecipitation? We examine the assumption and implications for ChIP and ChIP-seq.
Knockout cell lines and modulating the target's phosphorylation state are experimental controls that can be used to confirm specificity of your cell type.
Learn about host-based and dye-conjugated methods for IF multiplexing, as well as a sequential labeling strategy that works with indirect detection.
Zika virus turns off Akt signaling to hijack autophagy in developing neural tissue
Macrophages and novel predictive biomarkers: an overview of the opportunities and challenges in the tumor microenvironment.
Research is resource-intensive. Learn lab sustainability tips to reduce energy usage, conserve water, mitigate plastic waste, and practice green chemistry.
Sample fixation and permeabilization steps can impact the success of your experiment because antibodies perform differently using different protocols.
Apoptosis is a regulated form of programmed cell death (PCD) that occurs without external influence.
Biological imaging data has been increasing in complexity. This opens up the opportunity for a host of insights regarding spatial relationships.
There are many reasons to include a subcellular marker in your IF experiment: studying organelle-specific functions, assessing drug effects, and more.
Changing the primary antibody dilution and incubation conditions affects fluorescence intensity and signal-to-noise ratio in IF experiments.
A scientific resource for the BIR protein domain containing information on structure, function, and domain binding in apoptosis.