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Explore the mitochondrial apoptosis pathway and its role in programmed cell death. Read more about this essential pathway here.
Apoptosis is a type of programmed cell death that occurs normally throughout the lifespan and can also occur in response to harmful stimuli. Apoptotic cells are identified by their altered morphology, caspase activation, and the presence of damaged DNA.
Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.
Study the intricate machinery of the apoptosis signaling pathway. Click here to learn more and gain insights into programmed cell death mechanisms.
A scientific resource for the CARD protein domain containing information on structure, function, and domain binding during apoptosis.
Find out the best control cell extracts to use as positive or negative controls in your western blots, when studying apoptosis, autophagy, and mitophagy.
Cell viability is a measure of the proportion of live, healthy cells within a population. Assays to assess cell viability measure metabolic activity, ATP content, cell proliferation, or membrane integrity.
Products and Related Resources for Cell Death and Viability SARS-CoV-2 Research
A scientific resource for the BH protein domains containing information on structure, function, and domain binding in apoptosis.
Expert-reviewed interactive pathway providing a current overview of Death Receptor Signaling.
Video tutorials illustrate the science behind cellular processes and signaling pathways.
Expert-reviewed interactive pathway providing a current overview of Inhibition of Apoptosis Signaling.
Regulation of cell death due to viral infection is important for host survival. In this series, we look at pathways regulated through cellular responses to viruses.
Cytotoxicity is the ability of an exogenous agent to damage or kill cells. Measuring cytotoxicity can help determine the effect of drugs on cell viability.
Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways involved are Autophagy and Apoptosis.
Cancer cells can resist death. They evade apoptosis, the mechanism that programs cell death once cells become damaged. Normally, apoptosis helps keep an organism healthy through growth and development, but cancer cells do not follow this process, no matter how abnormally they grow.
Apoptosis is a regulated form of programmed cell death (PCD) that occurs without external influence.
Apoptosis is a highly regulated form of programmed cell death that occurs in multicellular organisms throughout life and in response to cellular stress.
Identify microglia by using these antibodies, which are designed to detect protein biomarkers specifically expressed within these cells.
Several different assays can be used by scientists to measure metabolism in a variety of contexts. These include methods to determine metabolic rates, key signaling pathways, and environmental cues.
Organelle markers for immunofluorescence analysis from CST Cell Signaling Technology
Loading controls are essential to ensure data reliability in your western blot. Learn about the three main considerations for loading control selection.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
Stem cell markers and kits organized in table format: links to product pages; includes Oct-4, Sox2, Nanog, c-Myc, C/EBPα, LIN28 and KLF4.
PathScan Sandwich ELISA Protocol Colormetric: easy to follow directions describing the step by step experimental procedure.
PathScan Sandwich ELISA Protocol (for kits with Lyophilized Antibodies) from Cell Signaling Technology with recommended companion products.
PathScan Sandwich ELISA Antibody Pair Protocol: easy to follow directions describing the step by step experimental procedure.
Immunoprecipitation Protocol (For Analysis By Kinase Assay): easy to follow directions describing the step by step experimental procedure.