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The key to identifying neurons, microglia, oligodendrocytes, and astrocytes lies in using antibodies that target protein biomarkers specifically expressed and localized within these cells.
There are a number of markers that can be used to distinguish the many cell types of the central and peripheral nervous system during development, adult neurogenesis, and the pathogenesis of neurodegenerative disorders.
Identify microglia by using these antibodies, which are designed to detect protein biomarkers specifically expressed within these cells.
Streamline your neurodegeneration therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
This guide includes some of the most common markers used to detect neuronal and glial cells, which include oligodendrocytes, astrocytes, and microglia.
Biological imaging data has been increasing in complexity. This opens up the opportunity for a host of insights regarding spatial relationships.
Neuroinflammation is the activation of an immune response in the CNS by the microglia and astrocytes. While not linked mechanistically to neurodegenerative diseases, neuroinflammation is associated with the progression of Alzheimer’s disease, Parkinson’s
A broad range of techniques are used to study neurodegenerative diseases including basic cellular and molecular protocols, ELISA, electrophysiological assessments, and imaging-based methods that utilize antibody-based technology.
Studying neurodegenerative disease? Get the most from your sample: consider the research question being posed, the sample type, and available techniques.
Chronic neuroinflammation is associated with neurodegenerative diseases like Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and others.
Tau is a microtubule-associated protein found in neurons, and its function is to stabilize axonal microtubules. Hyperphosphorylated tau is a hallmark of several neurodegenerative diseases including Alzheimer’s disease.
Learn about host-based and dye-conjugated methods for IF multiplexing, as well as a sequential labeling strategy that works with indirect detection.
The immune system is composed of tissues, cells, and molecules whose primary function is to detect, respond to, and eliminate pathogens and transformed cells.
Expert-reviewed interactive diagrams providing current overviews of neuronal and glial cell markers, as well as links to products from CST.
Non-neuronal cells like microglia and astrocytes play critical roles in maintaining proper neuronal function, development, and disease.
New antibodies for Alzheimer's research were presented at SfN 2022, including tools to study neuroinflammation in glial cells like microglia and astrocytes
Expert-reviewed interactive signaling pathways providing current overviews of the regulation of actin and microtubule dynamics, as well as links to products from CST.
Zika virus turns off Akt signaling to hijack autophagy in developing neural tissue
Co-staining with multiple antibodies is a low-content form of multiplex analysis that be achieved using different host species or fluorophore conjugates.
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.
Therapeutic developments in treating Alzheimer’s, novel diagnostic tools, and new insights into neurodegeneration mechanisms were key topics at AD/PD 2023.
Our GFP Antibody #2555, GFP (D5.1) Rabbit mAb #2956, GFP (4B10) Mouse mAb #2955, and GFP (5G4) Mouse mAb #55494 are not expected to detect hrGFP.
Yes, the GFP (D5.1) Rabbit mAb #2956 will detect Emerald GFP.
The GFP Antibody #2555, GFP (4B10) Mouse mAb #2955, GFP (5G4) Mouse mAb #55494, and GFP (D5.1) XP® Rabbit mAb #2956 are not expected to detect Turbo GFP due to low sequence homology.
Regrettably, none of our GFP antibodies will recognize ZsGreen and copGFP.
We have not tested any of our GFP antibodies against the citrine variant of YFP.
Our GFP (D5.1) Rabbit mAb #2956 is expected to detect EGFP, eBFP2, and mCerulean3.
Tissue clearing has paved the way for intact brain imaging with molecular phenotyping. The technology is rapidly evolving and shows great potential.
